Clinical trial · Interventional
FLOTOR Pilot Study
FLuOrescence to Identify the Thoracic Duct During Oesophageal Resections
NCT03292757CI-TRIAL-00035850FLOTORcompletedPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a non-randomised study assessing the technique of using indocyanine green as a fluorescent dye to highlight the thoracic duct during oesophectomy.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chylothorax | — | UNRESOLVED | — |
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Thoracic Duct Intra-Operative Injury | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Indocyanine Green | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Mesenteric ICG
- description
- Indocyanine green injected into the small bowel mesentery during oesophagectomy.
- interventionNames
- Drug: Indocyanine Green
- type
- EXPERIMENTAL
- label
- Feeding jejunostomy ICG (cream)
- description
- Indocyanine green mixed with cream infiltrated into the feeding jejunostomy.
- interventionNames
- Drug: Indocyanine Green
Primary outcomes (1)
- measure
- Number of thoracic ducts seen under fluorescence versus number of thoracic ducts seen with white light. (Change over time)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 years or above. * Undergoing elective oesophagectomy Exclusion Criteria: * Known allergy to iodine or ICG * Female patient who is pregnant, planning pregnancy or breastfeeding * Patient has a lactose intolerance (excluded only from receiving cream method) * Known significant liver failure
References
Publications (1)
- DERIVEDBarnes TG, MacGregor T, Sgromo B, Maynard ND, Gillies RS. Near infra-red fluorescence identification of the thoracic duct to prevent chyle leaks during oesophagectomy. Surg Endosc. 2022 Jul;36(7):5319-5325. doi: 10.1007/s00464-021-08912-1. Epub 2021 Dec 14. PMID 34905086