Interest of Fluorescein in Fluorescence-guided Resection of Gliomas (FLEGME)

Fluorescence guidance is a safe and efficient tool for glioblastomas resection. The most widely used technique is based on 5-aminolevulinic acid (5ala), which stains glioblastoma cells through a metabolic abnormality and thus helps in defining tumoral edges through a modified microscope. A multicentric, randomized study comparing 5ala guided surgery with conventional procedures showed that this technique doubles the rate of complete removal on post-operative magnetic resonance imaging (MRI), and increases the 6 months progression-free survival. More recently, fluorescein appeared as an interesting alternative fluorophore for glioblastomas, with a highly reduced cost (2.5 euros versus 1000 euros per dose). However its use remains scarcely studied and its clinical benefit unsure. In that context, the investigators propose a randomized trial comparing conventional " white light " surgery with fluorescein-guided resection of glioblastomas, in order to assess the relevance of this technique in glioblastomas removal.

Sex

All

Minimum age

18 Years

Maximum age

79 Years

Inclusion Criteria:

* Age between 18 and 79
* Karnofsky index \> 70 %
* Brain MRI showing a parenchymal lesion with typical features of glioblastoma, \< 1week
* Achievable gross total removal, as assessed by the neurosurgical staff
* Written consent

Exclusion Criteria:

* Contraindication to fluorescein
* Contraindication to MRI
* History of brain surgery \<6 months
* Guardianship, tutelage or deprivation of liberty
* Pregnancy or breastfeeding
* Participation to other interventional clinical studies