Clinical trial · Observational
Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer
Cohort Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In patients diagnosed as endometrial cancer by thorough pathologic examinations, Lynch syndromes are screened by (1)immunohistochemical staining (for MLH1, MSH2, MSH6 and PMS2), (2) tests of microsatellite instability and (3) clinical criteria (Amsterdam I or II criteria and Bethesda criteria). For patients with any suspicious discoveries of Lynch syndromes from aforementioned screening methods, a molecular diagnosis with next-generation sequencing for mismatch repair genes (MLH1, MSH2, MSH6, PMS2, and EPCAM) is given to confirm Lynch syndromes. For patients of Lynch syndromes and endometrial cancer, relatives of blood lineage are tested by Sanger method or qPCR to find out carriers of mutation genes of Lynch syndromes.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms, Hereditary Nonpolyposis | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.85 |
| Endometrial Neoplasms | Endometrial Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| clinical criteria of Lynch syndromes | Diagnostic Test | — | UNRESOLVED |
| immunohistochemical staining | Diagnostic Test | — | UNRESOLVED |
| sequencing for mismatch repair genes | Diagnostic Test | — | UNRESOLVED |
| tests of microsatellite instability | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Distribution of Lynch syndromes in endometrial cancer
- timeFrame
- 2 years
- description
- Proportions of patients carrying mismatch repair gene in endometrial cancer
Secondary outcomes (3)
- measure
- Reliability of immunohistochemical staining for screening Lynch syndromes
- timeFrame
- 2 years
- description
- Sensitiviy and specitiviy of immunohistochemical staining for screening Lynch syndromes
- measure
- Reliability of microsatellite instability for screening Lynch syndromes
- timeFrame
- 2 years
- description
- Sensitiviy and specitiviy of microsatellite instability for screening Lynch syndromes
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Survivals of endometrial cancer Exclusion Criteria: * Metatatic malignacies to uterine * Leiomyosarcoma of uterus
References
Publications (1)
- DERIVEDChao X, Li L, Wu M, Ma S, Tan X, Zhong S, Bi Y, Lang J. Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China. Cancer Commun (Lond). 2019 Jul 15;39(1):42. doi: 10.1186/s40880-019-0388-2. PMID 31307542