Clinical trial · Observational
Confocal Laser Endomicroscopy in Pleural Malignancies
Confocal Laser Endomicroscopy in Pleural Malignancies: A Comparison With Pathology
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To date, the different biopsy methods, such as CT-guided pleural biopsy, mediastinal biopsy, endosonography and thoracoscopy have their limitations in diagnosing pleural malignancies, such as mesothelioma. Sampling errors frequently occur resulting in the common histological finding of 'non-specific pleuritic/fibrosis', which presents a great uncertainty for clinicians and patients. Confocal laser endomicroscopy (CLE) provides real-time imaging on a cellular level, however data of CLE in pleural malignancies are lacking.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pleural Diseases | — | UNRESOLVED | — |
| Pleural Malignant Mesothelioma | Pleural Malignant Mesothelioma | ONTOLOGY_EXACT | 0.98 |
| Thymoma | Thymoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Confocal laser endomicroscopy | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Intrathoracic malignancy
- description
- Patients with (strong suspicion of) intrathoracic malignancy and an indication for tissue collection by CT-guided, transthoracic or thoracoscopic approach undergo additional imaging with confocal laser endomicroscopy (CLE).
- interventionNames
- Device: Confocal laser endomicroscopy
Primary outcomes (3)
- measure
- Technical feasibility: Number of successful procedures with evaluable CLE-imaging
- timeFrame
- cross sectional (1 day)
- description
- Number of successful procedures with evaluable CLE-imaging
- measure
- Procedure-related adverse events
- timeFrame
- cross sectional (1 day)
- description
- Number of study-related adverse events
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * ≥18 years of age * Supected intra-thoracic malignancies with pleural involvement and referred for a diagnostic procedure by thoracoscopy, CT guided biopsy or endosonography Exclusion Criteria: * Inability and willingness to provide informed consent * Patients with known allergy for fluorescein or risk factors for an allergic reaction * pregnancy or lactating women
References
Publications (0)
Data not yet available