Clinical trial · Interventional
Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line
Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study
NCT03288298CI-TRIAL-00029608unknownEarly Phase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma | Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Tongue Neoplasms | Tongue Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| luteolin | Drug | — | UNRESOLVED |
| nano-luteolin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- luteolin
- description
- a natural extract derived flavinoids
- interventionNames
- Drug: luteolin
- type
- ACTIVE_COMPARATOR
- label
- nano-luteolin
- description
- nano-particles derived from a natural extract luteolin
- interventionNames
- Drug: nano-luteolin
Primary outcomes (1)
- measure
- gene expression of Caspase 3 to detect apoptosis
- timeFrame
- 6 hours
- description
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Squamous cell carcinoma cell lines (OSCC, TSCC and HNSCC). * Luteolin 5,7,3',4'-tetrahydroxy-flavone (MeSH term). * Application of luteolin as a chemotherapeutic drug. Exclusion Criteria: * Any cancer cell line other than OSCC, TSCC and HNSCC cell lines. * Luteolin glycosides.
References
Publications (1)
- BACKGROUNDDing S, Hu A, Hu Y, Ma J, Weng P, Dai J. Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest. Tumour Biol. 2014 Apr;35(4):3053-60. doi: 10.1007/s13277-013-1396-5. Epub 2013 Nov 28. PMID 24287949