Clinical trial · Interventional
Can Exercise Training Reduce the Frequency and Severity of Hot Flushes Associated With Breast Cancer Treatment?
NCT03286257CI-TRIAL-00070419completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In brief, this study sets out to understand if exercise training can reduce the frequency and severity of hot flushes associated with breast cancer treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise Intervention | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Exercise Intervention
- description
- Participants will complete a partially supervised 4 month exercise program consisting of 3-5 sessions/week at a moderate intensity (40-75% heart rate (HR) reserve) at Liverpool Lifestyles gyms. Participants will be given free access to the Wellness Key System© when using the Lifestyles exercise equipment which allows researchers to remotely track the exercise intensity of participants accurately.
- interventionNames
- Behavioral: Exercise Intervention
Primary outcomes (2)
- measure
- Change in Thermoregulation
- timeFrame
- Change from pre- to post- 16 week exercise intervention
- description
- Participants will wear a tube-lined suit that allows manipulation of skin temperature by heating the water passed through the tubes. Core temperature will be increased by 1 degree (monitored using a temperature pill) with sweat rate and skin temperature recordings taken at 5minute intervals across 1 hour of heating. Thermoregulation will be compared during this hour to that of the post-exercise intervention re-test.
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Able to provide written informed consent * Pre-menopausal, Peri-menopausal or post-menopausal * \>4 hot flushes per day * Female * Treated with tamoxifen or aromatase inhibitor Exclusion Criteria: * Uncontrolled or severe hypertension (blood pressure \> 160/100 mm Hg) * Any previous injury preventing exercise * Type 1 or 2 diabetes * Anti-depressants * Currently undergoing chemotherapy or radiotherapy * Current smoker * Cannot readily read and understand English
References
Publications (0)
Data not yet available
No reference posted for this study.