Clinical trial · Observational
Stereotactic Radiotherapy for Brain Metastases
Stereotactic Radiotherapy for Patients With Brain Metastases
NCT03286023CI-TRIAL-00059218CKBrainMetaunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Stereotactic radiotherapy is an innovative treatment enabling to target accurately brain metastases. The aim of this study is to evaluate tumoral response and acute and late toxicity of this treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Metastasis Brain | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| stereotactic radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Stereotactic radiation
- description
- Stereotactic radiation for brain metastases
- interventionNames
- Radiation: stereotactic radiotherapy
Primary outcomes (2)
- measure
- Evaluation of tumoral response
- timeFrame
- 4 weeks after treatment
- description
- Evaluation of response using Magnetic resonance imaging (Recist criteria)
- measure
- Evaluation of tumoral response
- timeFrame
- 8 weeks after treatment
- description
- Evaluation of response using Magnetic resonance imaging (Recist criteria)
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Situation 1: in case of several cerebral metastases. In this case, the maximum of cerebral metastases is 3, and the maximum diameter of the largest can not exceed 3 cm. The other two ones can not exceed 1 cm or even maximum 2 cm in diameter for one of the two. The same principle will remain valid in the presence of 2 metastases. * Situation 2: in the case of a single metastasis, the diameter should be a maximum of 3 cm * Situation 3: in case of metastasis supposed to be radioresistant (renal adenocarcinoma, sarcoma, melanoma ...), only a single metastasis of not more than 3 cm in diameter will be accepted. A primary resection followed by radiotherapy will be preferred. * Situation 4: In case of localization near a structure at risk (contact with anterior optical pathways, central nuclei or the brainstem or localization in these structures), a maximum number of 3 metastases may be accepted. However, that included in or close to the risk structure can not exceed 2 cm in diameter and the other two, located outside a risk structure will have a diameter not exceeding 1 or even maximum 2 cm. * Situation 5: single metastasis of maximum 3 cm in a context of re-irradiation, the whole encephalon having already received the dose of 10 X 3 Gy or its biological equivalent of dose. * Signed informed consent Exclusion Criteria: * Impossibility of performing an MRI or a CT-scan of the brain with injection of contrast agent * Metastases greater than 3 cm at the start
References
Publications (0)
Data not yet available
No reference posted for this study.