Clinical trial · Observational
Kinetics of Perioperative Circulating DNA in Cancer Surgery
NCT03284684CI-TRIAL-00098145Periop ctDNAcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study was to determine the kinetics of perioperative circulating DNA in three types of cancer. This first step will enable further studies comparing the potential impact of certain techniques or anesthetic products on cancer surgery.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood test | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- circulating DNA plasma level test
- interventionNames
- Other: Blood test
Primary outcomes (4)
- measure
- Change in concentration of total mutant circulating DNA
- timeFrame
- Nine timepoints between Day-1 to Day 3
- description
- ng/mL in plasma
- measure
- Change in proportion of mutant circulating DNA
- timeFrame
- Nine timepoints between Day-1 to Day 3
- description
- ng/mL in plasma
- measure
- Change in integrity index of circulating DNA for ACTB gene
- timeFrame
- Nine timepoints between Day-1 to Day 3
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * The patient is aged between 18-75 * Patient must weigh \>40kg * The patient will receive adjusted carcinological surgery * Indication of curative surgery * The patient has already undergone tumoral biopsy prior to surgery * The patient has stage M0 cancer of either colon (right or left colonic adenocarcinoma), prostate (adenocarcinoma) or breast (infiltrating carcinoma) Exclusion Criteria: * The subject is in a period of exclusion determined by a previous study * The patient is under safeguard of justice * The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient is pregnant, parturient or breast feeding * Chronic alcoholism * The patient has received radiotherapy or chemotherapy periopratively * Cancer other than colon, breast or prostate * The patient has currently or in the past, had a cancerous lesion * Neo-adjuvant therapy (immunotherapy, radiotherapy, chemotherapy) * Emergency cancer surgery
References
Publications (1)
- RESULTKudriavtsev A, Pastor B, Mirandola A, Pisareva E, Gricourt Y, Capdevila X, Thierry AR, Cuvillon P. Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients. Precis Clin Med. 2024 Mar 27;7(2):pbae008. doi: 10.1093/pcmedi/pbae008. eCollection 2024 Jun. PMID 38699382