Clinical trial · Interventional
Epidural Steroids With Intrathecal Nalbuphine for Lower Abdominal Oncologic Surgery
Epidural Steroids Combined With Intrathecal Nalbuphine: Analgesic and Side Effects Concept in Lower Abdominal Surgical Oncology Procedures
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Intraoperative pain, nausea, vomiting, hypotension, bradycardia are known side effects during lower abdominal surgery under spinal anesthesia, Time to 2 segment regression of sensory block and duration of effective analgesia prolonged with intrathecal (IT) 0.4 mg nalbuphine \& IT 0.8 mg nalbuphine, but the incidence of side-effects was significantly higher with IT 0.8 mg nalbuphine compared with (IT) 0.4 mg nalbuphine.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lower Abdominal Oncologic Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexamethasone-nalbuphine | Drug | — | UNRESOLVED |
| Placebo-nalbuphine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Placebo-nalbuphine
- description
- Epidural injection of normal saline followed with intrathecal injection of 0.6 mg nalbuphine in conjunction with 4 ml of hyperbaric bupivacaine 0.5%
- interventionNames
- Drug: Placebo-nalbuphine
- type
- ACTIVE_COMPARATOR
- label
- Dexamethasone-nalbuphine
- description
- Epidural injection of dexamethasone followed with intrathecal injection of 0.6 mg nalbuphine in conjunction with 4 ml of hyperbaric bupivacaine 0.5%
- interventionNames
- Drug: Dexamethasone-nalbuphine
Primary outcomes (1)
- measure
- Pain score
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * American Society of Anesthesiologists physical class I or II. * Undergoing laparotomy * Undergoing oophorectomy * Undergoing hysterectomy * Undergoing rectal mass excision Exclusion Criteria: * Patient refusal. * Hypersensitivity to amide local anesthetics. * General contraindications to spinal anesthesia. * Cardiac diseases. * Hepatic failure. * Renal failure. * Respiratory failure. * Communication barriers.
References
Publications (0)
Data not yet available