Clinical trial · Interventional
Evaluation of Cerebral Elastography by Magnetic Resonance: Comparison of Healthy Subjects and Patients With Glial Tumor
The Relevance of Cerebral MRI Elastography in the Mechanical Characterization of Glial Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
MRI elastography detects the movement of tissues in the human body and monitors their response to mechanical stress in order to reveal their mechanical properties, like palpation. These depend on the structure of the tissues, their biological conditions and possible conditions. This non-invasive technique allows exploration of deep organs such as the brain that the doctor's hand can not reach. MRI elastography may prove to be an essential tool for study, diagnosis, staging and therapeutic monitoring of brain diseases. Neurodegenerative diseases (Alzheimer's, Parkinson's, Creutzfeldt-Jakobes) and cancers largely modify the mechanical properties of the affected tissues. For a first evaluation of the technique, we are interested in glial tumors representing half of the intracranial tumors in adults (incidence: 5 cases per 100 000 inhabitants), the second cancer in children and the third cause of death in l Young adult.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Elasticity Imaging Techniques | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Device for mechanical excitation by pressure waves | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Examination of cerebral MRI elastography
- description
- The mechanical waves will be induced by pressure waves guided to the mouth of the elongated subject in the MRI
- interventionNames
- Diagnostic Test: Device for mechanical excitation by pressure waves
Primary outcomes (1)
- measure
- normal values of cerebral MRI elastography in healthy volunteers
- timeFrame
- 1 month
- description
- Mechanical excitation by pressure waves
Secondary outcomes (2)
- measure
- Values of shear modulus of elasticity in the brain region explored
- timeFrame
- 1 month
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria for healthy subjects will be: * Age between 18 and 65 years * Ability to hold in an MRI device without moving * No known and diagnosed neurological pathologies such as stroke, cerebral surgery, central nervous system tumor, inflammatory disease (such as multiple sclerosis), neurodegenerative disease (such as Alzheimer's, Parkinson's or Creutzfeldt-Jakobes's ), depression * Informed consent Inclusion criteria for patients will be: * Age between 18 and 65 years * Ability to hold in an MRI device without moving * Glial tumor greater than 3 mm diagnosed by standard MRI * Informed and informed consent Exclusion Criteriafor both patients and healthy subjects will be: * Inability to perform an MRI examination : claustrophobia, presence of ferromagnetic metallic foreign bodies, wearing a pace-maker, metallic cardiac prosthetic valve, cochlear implants, vascular clips, insulin pump, pregnancy, breastfeeding.. * Non-affiliation to a social security scheme (beneficiary or beneficiary) * Intercurrent disorder likely to disrupt test results * Patient under anticoagulant:
References
Publications (0)
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