Clinical trial · Interventional
Adjuvant Radiotherapy for Esophageal Squamous Cell Carcinoma With Positive Circumstantial Resection Margin
Adjuvant Radiotherapy for T3N0M0 Esophageal Squamous Cell Carcinoma With Positive Circumstantial Resection Margin(a Randomized Controlled Trial)
NCT03273647CI-TRIAL-00029960unknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine the efficacy of adjuvant radiotherapy for esophageal squamous cell carcinoma with positive circumstantial resection margin.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Squamous Cell Carcinoma | Esophageal Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Positive Circumferential Resection Margin | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| radiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- surgery plus radiation
- description
- adjuvant radiotherapy is developed in this arm
- interventionNames
- Radiation: radiation
- type
- NO_INTERVENTION
- label
- surgery alone
- description
- No adjuvant radiotherapy,that is surgery alone is developed in this arm
Primary outcomes (1)
- measure
- Disease-free survival time
- timeFrame
- up to 3 years
- description
- including survival time from randomization to locoregional recurrence and to distal metastasis
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Patients with esophageal cancer who received R0 operations in Fudan University Shanghai Cancer Center and postoperative pathology: squamous cell cancer,positive Circumferential Resection Margin(CRM)+ * KPS≥70 before radiotherapy; * Did not receive neoadjuvant or adjuvant treatment; * No clear recurrent or metastatic lesions before radiotherapy; * Intensity modulated radiation therapy(IMRT) is accepted; * Regular follow-up. Exclusion Criteria: * Exploratory thoracotomy or palliative surgery; * No clear recurrent or metastatic sites; * Recurrence or metastasis is not certain; * death of no definite cause. * Irregular follow-up;
References
Publications (0)
Data not yet available
No reference posted for this study.