Clinical trial · Interventional
Sigmoid Colon Organ Motion in Radiotherapy
Interfraction and Intrafraction Organ Motion of the Sigmoid Colon in Patients With Colorectal Cancer Undergoing Adjuvant Radiotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Radiotherapy is used in cancer treatment to eradicate microscopic cancer cells to lower the risk of recurrence. The radiotherapy plan must account for organ movement inside the body to ascertain adequate dose is delivered to the target. Knowledge of the magnitude is crucial to radiotherapy treatment planning. This study aims to quantify the movement of the sigmoid colon between different fractions of radiotherapy treatment (interfraction motion) and within the same fraction (intrafraction motion). This knowledge will help us determine the optimal margin to use in radiotherapy treatment planning.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sigmoid Cancer | — | UNRESOLVED | — |
| Sigmoid Colon Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Adjuvant image-guided radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Adjuvant image-guided radiotherapy
- description
- Adjuvant radiotherapy with image guidance via cone beam computed tomography. Treatment is identical to the current standard of care.
- interventionNames
- Radiation: Adjuvant image-guided radiotherapy
Primary outcomes (1)
- measure
- Interfraction sigmoid colon organ motion
- timeFrame
- 90 days
- description
- Offset of the sigmoid colon staple site in three axes (anterior-posterior, lateral, and cranial-caudal) compared to simulation CT
Secondary outcomes (2)
- measure
- Intrafraction sigmoid colon organ motion
- timeFrame
- 90 days
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with pathologically confirmed sigmoid colon cancer, who have received surgical excision (AR or LAR). * Anastomosis of the colon must be performed with a surgical stapler, with the staple visible on CT imaging. Exclusion Criteria: * Gross recurrent disease (defined as visible mass on CT imaging) in the pelvis. * Other malignancy within the pelvic cavity. * Previous surgery to the pelvic cavity other than AR/LAR. * Pregnant or lactating females. * Subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures.
References
Publications (0)
Data not yet available