Clinical trial · Interventional
Detection in Tandem Endocuff Cap Trial
Is Endocuff Vision Assisted Colonoscopy Superior to Cap Assisted Colonoscopy to Detect Adenomas
NCT03254498CI-TRIAL-00029142DETECTcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A randomised back to back study comparing cap and Endocuff to detect adenomas during colonoscopy
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenomas Serrated | — | UNRESOLVED | — |
| Colon Adenoma | Colon Adenoma | ONTOLOGY_EXACT | 0.98 |
| Colonic Neoplasms | Colon Neoplasm | ALIAS | 0.90 |
| Colo-rectal Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| cap assisted colonoscopy (CAC) | Device | — | UNRESOLVED |
| Endocuff | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Endocuff assisted colonoscopy
- description
- Participants are randomised to undergo first either with Endocuff or cap assisted colonoscopy during colonoscopy.
- interventionNames
- Device: Endocuff
- type
- PLACEBO_COMPARATOR
- label
- Cap assisted colonoscopy
- description
- Participants are randomised to undergo first either with Endocuff or cap assisted colonoscopy during colonoscopy.
- interventionNames
- Device: cap assisted colonoscopy (CAC)
Primary outcomes (1)
- measure
- Adenoma miss rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age 18 years and over 2. Referral for surveillance, or diagnostic colonoscopy 3. Ability to give informed consent Exclusion Criteria: 1. Absolute contraindications to colonoscopy 2. Established or suspicion of large bowel obstruction or pseudo-obstruction 3. Known colon cancer or polyposis syndromes 4. Known colonic strictures 5. Known severe diverticular segment (that is likely to impede colonoscope passage) 6. Patients with active colitis (ulcerative colitis, Crohn's colitis, diverticulitis, infective colitis) 7. Patients lacking capacity to give informed consent 8. Pregnancy 9. Patients who are on clopidogrel, warfarin, or other new generation anticoagulants who have not stopped this for the procedure
References
Publications (1)
- DERIVEDRameshshanker R, Tsiamoulos Z, Wilson A, Rajendran A, Bassett P, Tekkis P, Saunders BP. Endoscopic cuff-assisted colonoscopy versus cap-assisted colonoscopy in adenoma detection: randomized tandem study-DEtection in Tandem Endocuff Cap Trial (DETECT). Gastrointest Endosc. 2020 Apr;91(4):894-904.e1. doi: 10.1016/j.gie.2019.11.046. Epub 2019 Dec 10. PMID 31836474