Clinical trial · Interventional
Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Brain Tumor Surgery
Effect of Single High Dose Vitamin D3 on Peri-operative and Post-operative Complications and Clinical Outcomes in Patients Under Craniotomy for Brain Tumor Resection
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Vitamin D supplementation not only has beneficial effects on morbidity and mortality in critically ill patients but it may also lead to alleviate of seizure, brain edema, infection, pain and some other perioperative complications, possibly in part through an attenuation of the immune response.In this trial patients with brain tumor under craniotomy will receive a single high dose vitamin D compared to control group.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| control | Other | — | UNRESOLVED |
| vitamin D | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- vitamin D
- description
- Intervention patients will be received a single dose of 300000 IU vitamin D via intramuscular injection
- interventionNames
- Drug: vitamin D
- type
- OTHER
- label
- control
- description
- Control patients will not be received any intervention
- interventionNames
- Other: control
Primary outcomes (1)
- measure
- Vitamin D level
- timeFrame
- Postoperative day 5
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Written informed consent of patient or legal representative * 25(OH)D level below 20ng/dL Exclusion Criteria: * Other trial participation, including previous participation in the pilot trial * Pregnant or lactating women * Hypercalcemia * Hyperphosphatemia * Tuberculosis * Sarcoidosis * History of nephrolithiasis * History of hyperparathyroidis * Medications that interfere with vitamin D metabolism * Renal Insufficiency
References
Publications (1)
- DERIVEDHajimohammadebrahim-Ketabforoush M, Shahmohammadi M, Keikhaee M, Eslamian G, Vahdat Shariatpanahi Z. Single high-dose vitamin D3 injection and clinical outcomes in brain tumor resection: A randomized, controlled clinical trial. Clin Nutr ESPEN. 2021 Feb;41:153-159. doi: 10.1016/j.clnesp.2020.11.027. Epub 2021 Jan 2. PMID 33487259