Clinical trial · Interventional
HEAD-US SCORING SYSTEM: Assessment of the Real-world Impact of Ultrasound
HEAD-US SCORING SYSTEM: Assessment of the Real-world Impact of Ultrasound on Disease Management and Treatment Decision-making in Moderate and Severe Haemophilia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Ultrasound represents a promising technique for the assessment of joint health in persons with haemophilia (PWH) by non-imaging specialists. The Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) programme has been developed with the aim of integrating joint ultrasound in the routine assessment of PWH through the use of a simplified scoring system. The inter-operator reliability of the technique among European haemophilia treaters has been validated and described elsewhere. Further work is needed to assess the real-world impact of ultrasound on disease management and treatment decision-making.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Moderate and Severe Haemophilia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| HEAD-US scoring system | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Single
- description
- All patients will undergo ultrasound scan using the HEAD-US Scoring System by a non-imaging specialist
- interventionNames
- Other: HEAD-US scoring system
Primary outcomes (1)
- measure
- Any change in treatment
- timeFrame
- 12 months
- description
- Any change in treatment including, management of a bleed and/or change in routine treatment protocol (including changes to prophylaxis regimen, or decision to start/stop prophylaxis regimen) as a result of the ultrasound findings
Secondary outcomes (2)
- measure
- % joints with normal HJHS and abnormal HEAD-US score
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
Show eligibility criteria text
Inclusion Criteria: * Moderate (FVIII/FIX:C 1-5%) and severe (FVIII/FIX: C \<1%) patients with haemophilia A or B aged ≥ 6 years * On demand or prophylaxis treatment regimen Exclusion Criteria: * Joints with a previous history of surgery * Joints with damage as a result of causes other than haemophilia-related bleeding
References
Publications (0)
Data not yet available