Clinical trial · Observational
Meta-Analyses of Low-risk Lifestyle Behaviours and Patient Important Outcomes
Relation of Low-risk Lifestyle Behaviours With Cardiovascular Disease, Diabetes, Cancer and All-Cause Mortality: A Series of Systematic Reviews and Meta-analyses of Prospective Cohort Studies
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Public health policy is universal in recommending the adoption of low risk low-risk lifestyle behaviors for health promotion and prevention of chronic or non-communicable diseases (NCDs).These behaviors generally include achieving and maintaining a healthy body weight, healthy diet, regular physical activity, smoking cessation, moderate alcohol intake, and adequate sleep. While there is a general consensus that adherence to any one of these low-risk lifestyle behaviors is associated with benefit, it is not clear if adherence to multiple behaviors would result in a larger benefit across different groups of people, conditions, and chronic disease outcomes. The Canadian Cardiovascular Society (CCS), as part of the Dyslipidemia Guidelines Update, commissioned a series of systematic reviews and meta-analyses (a type of knowledge synthesis) using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to quantify the benefit of adherence to multiple low-risk lifestyle behaviors in relation to patient-important chronic disease outcomes (risk of cardiovascular disease, diabetes, cancer, and death) and assesses the quality and strength of the evidence for this benefit.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cardiovascular Disease | — | UNRESOLVED | — |
| Diabetes | — | UNRESOLVED | — |
| Mortality | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low-risk lifestyle behaviours | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (4)
- measure
- Cardiovascular disease
- timeFrame
- Up to 20 years
- description
- Cardiovascular disease incidence and mortality, coronary heart disease incidence and mortality, stroke incidence and mortality
- measure
- Diabetes
- timeFrame
- Up to 20 years
- description
- Diabetes incidence
- measure
- Cancer
- timeFrame
- Up to 20 years
- description
- Cancer incidence and mortality
- measure
- All-cause mortality
- timeFrame
- Up to 20 years
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Prospective cohort studies Inclusion Criteria: * Prospective cohort studies or case-cohort studies * Duration \>= 1 year * Assessment of exposures of adherence to at-least three low-risk lifestyle behaviors, one of which must include a healthy diet * Ascertainment of clinical outcome data for cardiovascular disease, diabetes, cancer, or all-cause mortality by level of exposure Exclusion Criteria: * Ecological, cross-sectional, and retrospective observational studies, clinical trials, and non-human studies * Duration \< 1 year * No viable exposures data * No viable clinical outcome data
References
Publications (12)
- BACKGROUNDStampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med. 2000 Jul 6;343(1):16-22. doi: 10.1056/NEJM200007063430103. PMID 10882764
- BACKGROUNDSumamo E, Ha C, Korownyk C, Vandermeer B, Dryden DM. Lifestyle Interventions for Four Conditions: Type 2 Diabetes, Metabolic Syndrome, Breast Cancer, and Prostate Cancer [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 May 26. Available from http://www.ncbi.nlm.nih.gov/books/NBK254022/ PMID 25473696
- BACKGROUNDHu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, Willett WC. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med. 2001 Sep 13;345(11):790-7. doi: 10.1056/NEJMoa010492. PMID 11556298
- BACKGROUNDLoef M, Walach H. The combined effects of healthy lifestyle behaviors on all cause mortality: a systematic review and meta-analysis. Prev Med. 2012 Sep;55(3):163-70. doi: 10.1016/j.ypmed.2012.06.017. Epub 2012 Jun 24. PMID 22735042
- BACKGROUNDMozaffarian D, Afshin A, Benowitz NL, Bittner V, Daniels SR, Franch HA, Jacobs DR Jr, Kraus WE, Kris-Etherton PM, Krummel DA, Popkin BM, Whitsel LP, Zakai NA; American Heart Association Council on Epidemiology and Prevention, Council on Nutrition, Physical Activity and Metabolism, Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on the Kidney in Cardiovasc. Population approaches to improve diet, physical activity, and smoking habits: a scientific statement from the American Heart Association. Circulation. 2012 Sep 18;126(12):1514-63. doi: 10.1161/CIR.0b013e318260a20b. Epub 2012 Aug 20. PMID 22907934
- BACKGROUNDHiggins JPT, a.G.S. Cochrane Handbook for Systematic Reviews and Interventions, version 5.1.0 Updated March 2011. . Accessed at http://handbook.cochrane.org/ on September 25, 2014.
- Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000 Apr 19;283(15):2008-12. doi: 10.1001/jama.283.15.2008.