Clinical trial · Interventional
Mechanically-assisted Ventilation in the Treatment of Moving Tumours With Photon and Proton Therapies
Added Value of Mechanically-assisted Ventilation in the Treatment of Moving Tumours (Thoracic/Upper Abdomen) With Photon and Proton Therapies.
NCT03226925CI-TRIAL-00039476completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Mechanical ventilation can be used to impose a completely regular pattern of breathing frequency and inflation volume on the patient for as long as required. This would considerably improve the reproducibility of the internal motion parameters, and thus facilitate the implementation of respiratory-synchronized techniques such as gating, tracking and four-digital optimization.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Radiotherapy; Complications | — | UNRESOLVED | — |
| Thoracic Neoplasm | Thoracic Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Ventilator Lung | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dynamic MRI acquisition | Diagnostic Test | — | UNRESOLVED |
| Non-invasive mechanically-assisted ventilation | Diagnostic Test | — | UNRESOLVED |
| Planning 4D-CT | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Healthy volunteers on ventilation
- description
- Dynamic MRI acquisition will be performed at two different time points with 10 healthy volunteers under non-invasive mechanically-assisted ventilation with a respirator. Different modes will be compared (spontaneous, physiologic, shallow, slow and jet ventilation).
- interventionNames
- Diagnostic Test: Non-invasive mechanically-assisted ventilation
- Diagnostic Test: Dynamic MRI acquisition
- type
- EXPERIMENTAL
- label
- Cancer patients on ventilation
- description
- Dynamic MRI acquisition will be performed at two different time points with 10 patients (intended for a radiation treatment of their thoracic or upper abdominal tumours) under non-invasive mechanically-assisted ventilation with a respirator. Different modes will be compared (spontaneous, physiologic, shallow, slow and jet ventilation).
- interventionNames
- Diagnostic Test: Non-invasive mechanically-assisted ventilation
- Diagnostic Test: Dynamic MRI acquisition
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * No comorbidity for healthy volunteers * Cancer patients with either lung or upper abdomen (liver/pancreas) tumours treated with radiation therapy. Exclusion Criteria: * severe lung disease or emphysema * previous history of pneumothorax * claustrophobia
References
Publications (0)
Data not yet available
No reference posted for this study.