Clinical trial · Observational
Kuopio Ischaemic Heart Disease Risk Factor Study (Nutrition Component)
NCT03221127CI-TRIAL-00038240active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To determine associations between dietary factors and risk of major chronic diseases and their risk factors
Conditions
Conditions (13)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Atherosclerosis | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cardiovascular Diseases | — | UNRESOLVED | — |
| Chronic Disease | — | UNRESOLVED | — |
| Cognitive Decline | — | UNRESOLVED | — |
| Death | — | UNRESOLVED | — |
| Depression | — | UNRESOLVED | — |
| Diabetes | — | UNRESOLVED | — |
| Infection | — | UNRESOLVED | — |
| Inflammatory Disease | — | UNRESOLVED | — |
| Liver Diseases | — | UNRESOLVED | — |
| Metabolic Syndrome | — | UNRESOLVED | — |
| Pain, Chronic |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Cardiovascular disease
- timeFrame
- Annually between March 1984 and December 2052
- description
- Incidence of cardiovascular disease
- measure
- Carotid atherosclerosis
- timeFrame
- From baseline to 4-y, 11-y and 20-y examinations
- description
- Progression of common carotid artery - intima-media thickness (CCA-IMT)
- measure
- Death
- timeFrame
- Annually between March 1984 and December 2052
- description
- Incidence of death
Secondary outcomes (4)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 42 Years
- Maximum age
- 73 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 42, 48, 54 or 60 years (men at baseline in 1984-1989) * Aged 53 to 73 years (women at their baseline in 1998-2001) * Living in the city of Kuopio or neighboring rural areas Exclusion Criteria: * Condition that prevented visit at study clinic
References
Publications (5)
- DERIVEDHockey M, Hoare E, Mohebbi M, Tolmunen T, Hantunen S, Tuomainen TP, Macpherson H, Staudacher H, Jacka FN, Virtanen JK, Rocks T, Ruusunen A. Nonfermented Dairy Intake, but Not Fermented Dairy Intake, Associated with a Higher Risk of Depression in Middle-Age and Older Finnish Men. J Nutr. 2022 Aug 9;152(8):1916-1926. doi: 10.1093/jn/nxac128. PMID 35652820
- DERIVEDYlilauri MPT, Voutilainen S, Lonnroos E, Virtanen HEK, Tuomainen TP, Salonen JT, Virtanen JK. Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2019 Dec 1;110(6):1416-1423. doi: 10.1093/ajcn/nqz148. PMID 31360988
- DERIVEDAbdollahi AM, Virtanen HEK, Voutilainen S, Kurl S, Tuomainen TP, Salonen JT, Virtanen JK. Egg consumption, cholesterol intake, and risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2019 Jul 1;110(1):169-176. doi: 10.1093/ajcn/nqz066. PMID 31095282
- DERIVEDVirtanen HEK, Voutilainen S, Koskinen TT, Mursu J, Kokko P, Ylilauri MPT, Tuomainen TP, Salonen JT, Virtanen JK. Dietary proteins and protein sources and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2019 May 1;109(5):1462-1471. doi: 10.1093/ajcn/nqz025. PMID 30968137
- DERIVEDVirtanen HEK, Voutilainen S, Koskinen TT, Mursu J, Tuomainen TP, Virtanen JK. Intake of Different Dietary Proteins and Risk of Heart Failure in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study. Circ Heart Fail. 2018 Jun;11(6):e004531. doi: 10.1161/CIRCHEARTFAILURE.117.004531. PMID 29844244