Clinical trial · Interventional
"En Bloc" Resection of NMIBC: a Prospective， Single Centre，Randomized Study
Comparison of the Pathological Stage and Clinical Outcome of en Bloc Transurethral Resection by HybridKnife or Laser Versus Conventional Transurethral Resection for NMIBC: a Prospective, Single Centre, Randomized Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The traditional method of choice for intravesical resection of bladder tumors is conventional transurethral resection of bladder tumor (cTURBT). However, there has long been an ambition to overcome its biggest limitation, tumor fragmentation. Possible consequences include cell seeding and poor specimen quality, including missing detrusor muscle, thermal tissue damage, and tissue fragmentation. En bloc resection of bladder tumor (ERBT) represents an alternative technique for resection of bladder tumors. There is no doubt that ERBT has huge potential. ERBT provides specimens of high quality that are easy for pathologists to read. In theory, this may sustainably change the view on secondary resection, lead to faster decisions on subsequent treatments, and influence patient prognosis. Thus, there is an urgent need to compare ERBT with cTURBT in a thoroughly planned trial.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-muscle Invasive Bladder Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laser en Bloc Resection | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Laser en Bloc Resection
- description
- Laser en Bloc Resection of bladder tumor(laser ERBT)
- interventionNames
- Device: Laser en Bloc Resection
- type
- EXPERIMENTAL
- label
- Hydroknife en Bloc Resection
- description
- Hydroknife en Bloc Resection of bladder tumor (Hydroknife ERBT)
- interventionNames
- Device: Laser en Bloc Resection
- type
- EXPERIMENTAL
- label
- conventional transurethral resection
- description
- conventional transurethral resection of bladder tumor(cTURBT)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Pathological or histological diagnosis by cystoscopy of primary non-muscle invasive bladder urothelial carcinoma (Ta, T1); 2. Imaging examinations showed the bladder muscle has not been affected, no lymph node metastasis or distant metastasis; 3. Diameter of tumor 1-3cm 4. Number of lesions≤3 (The position of small lesions relatively concentrated as one place) 5. Patients who agree to ERBT or cTURBT surgery, and will be effected to the postoperative follow-up treatment such as conventional infusion after the operation Exclusion Criteria: 1. Tis or non-transitional epithelial tumors 2. Pathological or imaging examinations showed the bladder muscle has not been affected 3. There has surgery contraindications, such as bladder fibrosis 4. Diameter of tumor \>3cm or \<1cm 5. Number of lesions\>3 6. Anteriorly located tumor 7. Received chemotherapy or BCG perfusion therapy in the nearly 3 months 8. Poor performance status is difficult to tolerate surgery 9. The patient refused to sign a consent form
References
Publications (0)
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