Clinical trial · Interventional
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
Comparison of the Effects of Norepinephrine and Phenylephrine on Tissue Oxygenation and Hemodynamic Stability During an SVV Fluid Guided Therapy in Elderly Undergoing Radical Resection of Colon Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A prospective, double-blinded study. The present study consisted in applying Stroke volume variation fluid guided therapy to old patients (65 years old) undergoing radical resection of colon surgery. The aim of this study is to compare the effects of norepinephrine and phenylephrine in treating perioperative hypotension, and to find the safest and most effective vasopressor for elderly.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Fluid Therapy | — | UNRESOLVED | — |
| Hypotension | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Norepinephrine | Drug | — | UNRESOLVED |
| phenylephrine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- phenylephrine and norepinephrine
- description
- Phenylephrine 100ug/ml and Norepinephrine 5ug/ml IV infusion at a rate of 5 ml/h in case of perioperative hypotension.
- interventionNames
- Drug: phenylephrine
- Drug: Norepinephrine
- type
- OTHER
- label
- Norepinephrine and phenylephrine
- description
- Phenylephrine 100ug/ml and Norepinephrine 5ug/ml IV infusion in postoperative time in case of hypotension
- interventionNames
- Drug: phenylephrine
- Drug: Norepinephrine
Primary outcomes (1)
- measure
- the tissue oxygenation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
- Maximum age
- 95 Years
Show eligibility criteria text
Inclusion Criteria: * Operation time should be equal or greater than 2h, * Patients older than 65 years old, * ASA Ⅱ or Ⅲ. Exclusion Criteria: * Clear arrhythmia, * Need to apply PEEP, * Peripheral vascular disease and arterial catheter contraindications.
References
Publications (0)
Data not yet available