Clinical trial · Interventional
Effect of Treatment of Low Anterior Resection Syndrome After Rectal Cancer Surgery
A Randomized Controlled Study of the Effect of Treatment of Low Anterior Resection Syndrome (LARS) After Rectal Cancer Surgery
NCT03215017CI-TRIAL-00064568completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A randomized controlled trial (RCT) in patients who underwent sphincter preserving surgery due to rectal cancer. The study will analyze the effect of Transanal irrigation (TAI) and medication that can help control of the bowel movement in patients with low anterior resection syndrome.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Low Anterior Resection Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Medication | Drug | — | UNRESOLVED |
| Transanal irrigation | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Transanal irrigation
- description
- Manual transanal irrigation to control bowel function.
- interventionNames
- Device: Transanal irrigation
- type
- ACTIVE_COMPARATOR
- label
- Medication
- description
- Medication to control bowel function.
- interventionNames
- Drug: Medication
Primary outcomes (2)
- measure
- Bowel function
- timeFrame
- 1 year
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients that have undergone surgery for rectal cancer (sphincter saving surgery, low anterior resection) * Adult ≥ 18 years old * Have scoring major LARS (according to the Low anterior resection syndrome score) Exclusion Criteria: * stoma * recurrent disease * Another colorectal surgery * Inflammatory bowel disease (IBD)
References
Publications (1)
- BACKGROUNDPieniowski EHA, Bergstrom CM, Nordenvall CAM, Westberg KS, Johar AM, Tumlin Ekelund SF, Larsson KR, Pekkari KJ, Jansson Palmer GC, Lagergren P, Abraham-Nordling M. A Randomized Controlled Clinical Trial of Transanal Irrigation Versus Conservative Treatment in Patients With Low Anterior Resection Syndrome After Rectal Cancer Surgery. Ann Surg. 2023 Jan 1;277(1):30-37. doi: 10.1097/SLA.0000000000005482. Epub 2022 Jul 7. PMID 35797618