Clinical trial · Observational
Structural Network on Prostate Cancer in the French Greater West Region
Réseau Structurant Sur le Cancer de la Prostate du Grand Ouest
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The project aims at developing and structuring a network of clinicians, pathologists, and scientists, from the "Grand Ouest" area, most of them already involved in prostate cancer management and research. Patients treated by radical prostatectomy will be recruited within the ReSCaP network of clinicians, with centralized database and standardized bio-resource collection, including prostate and adipose tissue samples. Seven clinical centers will participate to the network, 6 recruiting mainly Caucasian patients, and 1 from the French West Indies recruiting mainly African Caribbean patients. After 18 months, 1000 patients will be included. The main goal is to study the relationships between adipose tissue/lipids and prostate cancer aggressiveness. In fact, adipose tissue is likely to be involved in cancer progression at many levels: abdominal obesity has been associated with aggressive disease, and poly-unsaturated fatty acids (PUFAs), as well as cytokines produced by adipocytes (adipokines) have an impact on cancer cells growth and migration in vitro. Moreover, adipose tissue is the preferential site of storage of persistent organic pollutants with estrogenic properties, which could impact cancer progression. The study will analyze the association between adipose tissue (distant from the prostate) composition and cancer aggressiveness. Among the 1000 patients, 100 aggressive tumors will be selected according to the d'Amico criteria (Gleason score 8 or more and/or pT3 tumors). They will be matched with 100 potentially indolent prostate cancers (Gleason 6 or less, and PSA less than 10, and pT2 stage on the surgical specimen). These 200 adipose tissue samples will be analyzed for 1/ the lipid profile, including the fatty acid composition, particularly PUFAs, that reflects past dietary fat intake, 2/ adipokine expression, and 3/ tissue concentrations of persistent organic pollutants belonging to the class of organochlorine pesticides with hormone-like activity.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Visceral adipose tissue specimen | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Prostatectomy
- description
- Visceral adipose tissue specimen sample
- interventionNames
- Procedure: Visceral adipose tissue specimen
Primary outcomes (1)
- measure
- Dietary intake of essential fatty acids
- timeFrame
- Participant exposure from birth until diagnosis date of Prostate Cancer
- description
- Past dietary intake of essential fatty acids is quantified by measuring their concentration in white adipose tissue
Secondary outcomes (1)
- measure
- Exposure to persistant organic pesticides
- timeFrame
- Participant exposure from birth until diagnosis date of Prostate Cancer
- description
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients treated for prostate cancer by radical prostatectomy without previous therapy * Informed written consent Exclusion Criteria: • Subject to deprivation of liberty, under guardianship or guardianship, under safeguard of justice, minor or major inability to express his or her consent
References
Publications (0)
Data not yet available