Clinical trial · Observational
Effect of Mannitol on Optic Nerve Sheath Diameter in Patients Undergoing Robotic Prostatectomy
Effect of Mannitol on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy: a Prospective Observational Study
NCT03214055CI-TRIAL-00029265completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
We aim to evaluate the change in optic nerve sheath diameters as a surrogate of intracranial pressure before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy with pneumoperitoneum and Trendelenburg position.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mannitol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Change in optic nerve sheath diameters
- timeFrame
- 5 minutes after pneumoperitoneum and Trendelenburg position, 90 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position
- description
- Change in optic nerve sheath diameters before and after mannitol administration
Secondary outcomes (4)
- measure
- Change in optic nerve sheath diameters
- timeFrame
- 5 minutes after pneumoperitoneum and Trendelenburg position, 60 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position
- description
- Change in optic nerve sheath diameters before and after mannitol administration
- measure
- Change in optic nerve sheath diameters
- timeFrame
- 5 minutes after pneumoperitoneum and Trendelenburg position, 30 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 20 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: * prostate cancer patients undergoing robot assisted laparoscopic radical prostatectomy. * 20 year old or above, 79 year old or below. * agreed to participate this study. Exclusion Criteria: * history of cerebrovascular accident. * history of congestive heart failure. * history of pulmonary edema. * history of anaphylaxis to mannitol. * conversion to open prostatectomy. * combined with other operation. * inability to measure optic nerve sheath diameter.
References
Publications (0)
Data not yet available
No reference posted for this study.