Clinical trial · Interventional
Impact of Adjuvant Chemotherapy in Patients With Colon Cancer
Impact of Adjuvant Chemotherapy in Cardiovascular Autonomic Regulation in Patients With Colon Cancer
NCT03213444CI-TRIAL-00037136completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The present study aims to investigate the impact of adjuvant chemotherapy with 5-FU isolated and associated with oxaliplatin in cardiac autonomic control and endothelium-dependent vascular function in patients undergoing colectomy for stages II and III colon cancer. Will be performed evaluation of cardiac and vascular function, autonomic control, functional capacity and blood evaluations.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adjuvant Chemotherapy | — | UNRESOLVED | — |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| adjuvant chemotherapy with 5-FU associated with oxaliplatin | Drug | — | UNRESOLVED |
| adjuvant chemotherapy with 5-FU isolated | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Quimioterapy 1
- description
- adjuvant chemotherapy with 5-FU isolated
- interventionNames
- Drug: adjuvant chemotherapy with 5-FU isolated
- type
- ACTIVE_COMPARATOR
- label
- Quimioterapy 2
- description
- adjuvant chemotherapy with 5-FU associated with oxaliplatin
- interventionNames
- Drug: adjuvant chemotherapy with 5-FU associated with oxaliplatin
Primary outcomes (1)
- measure
- cardiac function evaluation
- timeFrame
- Change from Baseline cardiac function at 6 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Scale of Performance Status 0 - 1 * Patients submitted to colectomy for adenocarcinoma of colon stages II and III. Exclusion Criteria: * Severe pulmonary disease * Decompensated cardiovascular disease * Neurological disease * Insulin-dependent diabetes mellitus * Dialysis renal insufficiency
References
Publications (0)
Data not yet available
No reference posted for this study.