Quantitative MR Imaging in Locally Advanced Cervical Cancer

Hypoxic tumour cells within the primary tumour have shown prognostic importance for local and metastatic disease control in several cancer sites. Radioresistant hypoxic cells diminish the rate of local control, and the hypoxia driven increase in metastatic potential of the tumour and lowers the rate of distant disease control. DCE MR imaging has been used to quantify the extent of poor perfusion regions within cervical tumours and it has been shown to be a surrogate of hypoxia. Furthermore, a number of studies have demonstrated that DCE MR is predictive of disease failure in cervix cancer. The EMBRACE II study will implement an imaging sub-study, which will evaluate the value of quantitative MR imaging to identify patients at increased risk of disease recurrence (local, nodal and systemic).

Sex

Female

Minimum age

18 Years

Inclusion Criteria:

* Patients included in the EMBRACE study (see inclusion criteria in the EMBRACE protocol)
* Patients without previous record of allergic reaction to infusion of protocol related contrast media (Gadolinium-based)
* Patients with sufficient kidney function according to local regulations
* Patient informed consent

Exclusion Criteria:

* According to EMBRACE II protocol
* Patients with active infection or severe medical condition

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