Clinical trial · Interventional
Effect of Plant and Animal Proteins on Biomarkers of Colorectal Cancer and Type 2 Diabetes in Healthy Adults (ScenoProt)
Effects of Dietary Plant and Animal Proteins on Biomarkers of Colorectal Cancer and Type 2 Diabetes in Healthy Adults
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to investigate the effects of dietary plant and animal proteins on gut metabolism and markers for colorectal cancer as well as blood protein metabolites and markers for type 2 diabetes in healthy adults. The study participants will be stratified into three groups with different protein composition in diets: 1) animal 70%/plant 30%; 2) animal 50%/plant 50% and 3) animal 30%/plant 70%. The participants will get part of their diet as ready foods or raw material to promote their compliance. The participants will also get personal advice for their diets. Blood, stool and urine samples will be collected in the beginning and in the end of the 12 week intervention, as well as phenotype measures like BMI, blood pressure and body composition. The participants will also fill food diary before and in the end of the intervention.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Type2 Diabetes | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 30% animal, 70% plant proteins in diet | Other | — | UNRESOLVED |
| 50% animal, 50% plant proteins in diet | Other | — | UNRESOLVED |
| 70% animal, 30% plant proteins in diet | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- 70% animal, 30% plant proteins in diet
- description
- Dietary proteins from animal sources 70% and from plant sources 30%, representing an average Finnish diet consumed at the moment.
- interventionNames
- Other: 70% animal, 30% plant proteins in diet
- type
- EXPERIMENTAL
- label
- 50% animal, 50% plant proteins in diet
- description
- Dietary proteins from animal sources 50% and from plant sources 50%, containing at most 500 g red meat/week (according to the current Finnish Nutrition Recommendations).
- interventionNames
- Other: 50% animal, 50% plant proteins in diet
- type
- EXPERIMENTAL
- label
- 30% animal, 70% plant proteins in diet
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 69 Years
Show eligibility criteria text
Inclusion Criteria: Healthy, no exclusion criteria listed below. Exclusion Criteria: Strict vegan, food allergies, oral medication for any allergies, regular use of food supplements, extreme sports, inflammatory bowel disease, colon irritable, caeliac disease, any kind of cancer within 5 years, continuous antibiotics or less than three months of the latest antibiotics use, type 1 or 2 diabetes, hormonal, liver or kidney disease, pregnancy, lactation.
References
Publications (3)
- DERIVEDSaarinen M, Pellinen T, Kostensalo J, Nousiainen J, Joensuu K, Itkonen ST, Pajari AM. Dietary climate impact correlates ambiguously with health biomarkers- a randomised controlled trial in healthy Finnish adults. Eur J Nutr. 2025 Feb 18;64(2):95. doi: 10.1007/s00394-025-03609-w. PMID 39964546
- DERIVEDPellinen T, Paivarinta E, Isotalo J, Lehtovirta M, Itkonen ST, Korkalo L, Erkkola M, Pajari AM. Replacing dietary animal-source proteins with plant-source proteins changes dietary intake and status of vitamins and minerals in healthy adults: a 12-week randomized controlled trial. Eur J Nutr. 2022 Apr;61(3):1391-1404. doi: 10.1007/s00394-021-02729-3. Epub 2021 Nov 27. PMID 34837522
- DERIVEDItkonen ST, Paivarinta E, Pellinen T, Viitakangas H, Risteli J, Erkkola M, Lamberg-Allardt C, Pajari AM. Partial Replacement of Animal Proteins with Plant Proteins for 12 Weeks Accelerates Bone Turnover Among Healthy Adults: A Randomized Clinical Trial. J Nutr. 2021 Jan 4;151(1):11-19. doi: 10.1093/jn/nxaa264. PMID 32939557