Clinical trial · Observational
Non-invasive Detection of Anastomotic Leakage
Non-invasive Detection of Anastomotic Leakage Following Esophageal and Pancreatic Surgery by Urinary Analysis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with malignant tumors of the esophagus or pancreatic head. These procedures are associated with high morbidity rates, which are strongly correlated with the occurrence of anastomotic leakage. Current diagnostic methods, including clinical, biochemical and radiological techniques are frequently inconclusive. Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of anastomotic leakage. Urinary volatile organic compounds reflect the metabolic status of an individual, which is associated with a systemic immunological response. The aim of this study was to determine the diagnostic accuracy of urinary volatile organic compounds to detect anastomotic leakage after esophagectomy or pancreaticoduodenectomy in an early phase.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomotic Leak | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Urinary volatile organic compound analysis | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Esophageal anastomotic leakage
- interventionNames
- Diagnostic Test: Urinary volatile organic compound analysis
- label
- Esophageal uncomplicated controls
- interventionNames
- Diagnostic Test: Urinary volatile organic compound analysis
- label
- Pancreatic anastomotic leakage
- interventionNames
- Diagnostic Test: Urinary volatile organic compound analysis
- label
- Pancreatic uncomplicated controls
- interventionNames
- Diagnostic Test: Urinary volatile organic compound analysis
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * Patients were aged 18-90 years * American Society of Anesthesiologists (ASA) physical status of 3 or lower * All participants were capable to understand the study information and signed written informed consent Exclusion Criteria: * None
References
Publications (0)
Data not yet available