Clinical trial · Observational
The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved
Comparison of the Effects of Total Intravenous Anesthesia and Inhalation Anesthesia on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and the Mechanism Involved: a Single-center, Randomized, Prospective Study
NCT03193710CI-TRIAL-00030181unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The body immunity is important to the development of tumor. The immune system is in charge of monitoring and cleaning tumor cells in circulation. Anesthesia may alter the immune response and affect the elimination of tumor cells. The purpose of the trial is to test whether inhalational anesthetic is relevant to tumor metastasis and recurrence of patients undergoing colorectal cancer resection through depression of lymphocytes-mediated immunity.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer Metastatic | — | UNRESOLVED | — |
| General Anesthetics Toxicity | — | UNRESOLVED | — |
| Lymphocyte Destruction | — | UNRESOLVED | — |
| Molecular Mechanism of Pharmacological Action | — | UNRESOLVED | — |
| Survival Rate | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Propofol | Drug | — | UNRESOLVED |
| Remifentanil | Drug | — | UNRESOLVED |
| Sevoflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Total intravenous anesthesia group
- description
- The anesthesia of patients in the total intravenous anesthesia group will be maintained with propofol and remifentanil.
- interventionNames
- Drug: Propofol
- Drug: Remifentanil
- label
- Inhalational anesthesia group
- description
- The anesthesia of patients in the inhalational anesthesia group will be maintained with sevoflurane and remifentanil.
- interventionNames
- Drug: Sevoflurane
- Drug: Remifentanil
Primary outcomes (2)
- measure
- Change from baseline lymphocytes within postoperative 5 years
- timeFrame
- up to 5 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * All the patients diagnosed with colonal or rectal cancer * Aged 18-65 * ASA I-III * Assigned to receive resection surgery under general anesthesia, with an expected duration of 2 hours or more * Agree to participate and give signed written informed consent. Exclusion Criteria: * Severe organic heart, liver and kidney diseases * Diabetes or hemopoietic disorders * Allergy to general anesthetics * Family historical malignant hyperthermia * Cognition dysfunction * End-stage cancer or with over 2 cancer metastasis, pathological results were benign tumor or TNM stage was over T1- 3N0 - 2M0 * Other primary malignant tumor * Immune deficiency or dysfunction or autoimmune disease or long-term usage of corticoids or immunosuppressants * Receiving general anesthesia within the last 3 months before the resection surgery * Perioperative transfusion
References
Publications (10)
- BACKGROUNDSofra M, Fei PC, Fabrizi L, Marcelli ME, Claroni C, Gallucci M, Ensoli F, Forastiere E. Immunomodulatory effects of total intravenous and balanced inhalation anesthesia in patients with bladder cancer undergoing elective radical cystectomy: preliminary results. J Exp Clin Cancer Res. 2013 Feb 3;32(1):6. doi: 10.1186/1756-9966-32-6. PMID 23374147
- BACKGROUNDQiao Y, Feng H, Zhao T, Yan H, Zhang H, Zhao X. Postoperative cognitive dysfunction after inhalational anesthesia in elderly patients undergoing major surgery: the influence of anesthetic technique, cerebral injury and systemic inflammation. BMC Anesthesiol. 2015 Oct 23;15:154. doi: 10.1186/s12871-015-0130-9. PMID 26497059
- BACKGROUNDMoller Petrun A, Kamenik M. Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial. Br J Anaesth. 2013 Mar;110(3):388-96. doi: 10.1093/bja/aes416. Epub 2012 Nov 19. PMID 23166149
- BACKGROUNDJaura AI, Flood G, Gallagher HC, Buggy DJ. Differential effects of serum from patients administered distinct anaesthetic techniques on apoptosis in breast cancer cells in vitro: a pilot study. Br J Anaesth. 2014 Jul;113 Suppl 1:i63-7. doi: 10.1093/bja/aet581. Epub 2014 Jul 9. PMID 25009197
- BACKGROUNDBuckley A, McQuaid S, Johnson P, Buggy DJ. Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: a pilot study. Br J Anaesth. 2014 Jul;113 Suppl 1:i56-62. doi: 10.1093/bja/aeu200. Epub 2014 Jul 9. PMID 25009196
- BACKGROUNDWigmore TJ, Mohammed K, Jhanji S. Long-term Survival for Patients Undergoing Volatile versus IV Anesthesia for Cancer Surgery: A Retrospective Analysis. Anesthesiology. 2016 Jan;124(1):69-79. doi: 10.1097/ALN.0000000000000936. PMID 26556730