Clinical trial · Observational
PET-guided External Beam Radiotherapy in Differentiated Thyroid Cancer
18F-FDG PET-guided External Beam Radiotherapy in Iodine-refractory Differentiated Thyroid Cancer
NCT03191643CI-TRIAL-00028164completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Description of the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Differentiated Thyroid Cancer | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- differentiated thyroid cancer
- description
- Patients with locally recurrent thyroid cancer, treated with radical radiotherapy after total thyroidectomy +/- central compartment and/or laterocervical lymphadenectomy, previously treated with one or more cycles of 131 Iodine-ablation (RAI) and TSH suppression.
Primary outcomes (1)
- measure
- Progression free survival (PFS)
- timeFrame
- 6 months
- description
- Progression-free survival (PFS) after radiotherapy is evaluated with CT-scan and 18F FDG PET-scan. Also laboratory tests are performed (HTG serum level evaluation in case of biochemical recurrence).
Secondary outcomes (1)
- measure
- toxicities
- timeFrame
- 6 months
- description
- Acute and late toxicities after radiotherapy are assessed with CTCAE v. 4.03 and EORTC-RTOG scales, respectively.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * detectable thyroglobulin (Tg), * negative post-metabolic radiotherapy whole body scintigraphy, * no surgical indications. Exclusion Criteria: * prior radiotherapy in the head and neck area * pregnancy
References
Publications (1)
- DERIVEDFarina E, Monari F, Castellucci P, Romani F, Repaci A, Farina A, Zanirato Rambaldi G, Frezza G, Mazzarotto R, Cammelli S, Tagliaferri L, Autorino R, Deodato F, Macchia G, Cilla S, Valentini V, Fanti S, Morganti AG. 18F-FDG Pet-Guided External Beam Radiotherapy in Iodine-Refractory Differentiated Thyroid Cancer: A Pilot Study. J Thyroid Res. 2017;2017:9807543. doi: 10.1155/2017/9807543. Epub 2017 Oct 19. PMID 29201490