Clinical trial · Interventional
Comparison of Sublobar Resection and Lobectomy to Treat Lung Cancer
NCT03185754CI-TRIAL-00048150unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A multi-center prospective randomized trial in Taiwan to investigate whether sublobar resection, as compared to lobectomy, can offer equivalent clinical results to treat early non-small cell lung cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| lobectomy | Procedure | — | UNRESOLVED |
| Sublobar resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- early phase lung cancer
- description
- sublobar resection and lobectomy
- interventionNames
- Procedure: Sublobar resection
- Procedure: lobectomy
Primary outcomes (1)
- measure
- Disease-free survival (DFS)
- timeFrame
- 5 years
- description
- The time interval from randomization to the earliest onset of any of the following events: tumor local recurrence, distant metastasis, and mortality
Secondary outcomes (4)
- measure
- post-operative complication
- timeFrame
- 3 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion criteria: * Early non-small cell lung cancer (stage Ia) with diameter of two centimeters or less. * Tumor locating at the peripheral lung parenchyma (outer one third in CT imaging). * No suspected hilar or mediastinal lymph nodes metastasis in the CT or PET imaging study. Exclusion criteria: * Tumor diameter more than 2 centimeter * Hilar or mediastinal lymphnode metastasis by the cancer. * Patients received previous surgery in the ipsi-lateral lung * Lung tumor locating in the central lung parenchyma unable to obtain curative resection by sublobar resection. * Patients with poor cardiopulmonary function unsuitable for receiving surgical resection. * Patients who have multiple lung cancer or other suspicious lesion in the lung.
References
Publications (4)
- RESULTGinsberg RJ, Rubinstein LV. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg. 1995 Sep;60(3):615-22; discussion 622-3. doi: 10.1016/0003-4975(95)00537-u. PMID 7677489
- RESULTSienel W, Dango S, Kirschbaum A, Cucuruz B, Horth W, Stremmel C, Passlick B. Sublobar resections in stage IA non-small cell lung cancer: segmentectomies result in significantly better cancer-related survival than wedge resections. Eur J Cardiothorac Surg. 2008 Apr;33(4):728-34. doi: 10.1016/j.ejcts.2007.12.048. Epub 2008 Feb 7. PMID 18261918
- RESULTKodama K, Doi O, Higashiyama M, Yokouchi H. Intentional limited resection for selected patients with T1 N0 M0 non-small-cell lung cancer: a single-institution study. J Thorac Cardiovasc Surg. 1997 Sep;114(3):347-53. doi: 10.1016/S0022-5223(97)70179-X. PMID 9305186
- RESULTOkada M, Yoshikawa K, Hatta T, Tsubota N. Is segmentectomy with lymph node assessment an alternative to lobectomy for non-small cell lung cancer of 2 cm or smaller? Ann Thorac Surg. 2001 Mar;71(3):956-60; discussion 961. doi: 10.1016/s0003-4975(00)02223-2. PMID 11269480