Clinical trial · Interventional
Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, sperm cryopreservation should be offered to all pubertal male patients. For prepubertal boys, only the experimental option of testicular biopsy in order to cryopreserve testicular stem cells can be proposed. Primary aims \- To cryopreserve testicular tissue of prepubertal patient receiving highly gonadotoxic oncological treatment. Secondary aims * To cryopreserve testicular tissue after failure of sperm cryopreservation in pubertal patient with high risk of infertility * To create a database in order to record clinical and biological follow-up data * To create a research biobank for future research projects Multicentric study: HUG, CHUV, UKBB
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
| Fertility Disorders | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| testicular tissue biopsy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- testicular tissue cryopreservation
- interventionNames
- Procedure: testicular tissue biopsy
Primary outcomes (1)
- measure
- Number of pediatric cancer patient who will undergo testicular tissue cryopreservation for fertility preservation
- timeFrame
- 0-20 years
Secondary outcomes (2)
- measure
- Incidence of complications related to the testicular biopsy (safety)
- timeFrame
- 0-20 years
- description
- The safety will be assessed by recording the number of complications of the procedure (e.g. bleeding, infection, testicular atrophy)
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 3 Months
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Prepubertal patients aged 3 months and older * Peri and pubertal patients after failure of sperm cryopreservation * Patients presenting high risk of infertility because of gonadotoxic treatments (i.e high dose of alkylating agents, testicular irradiation, total body irradiation). * Multidisciplinary team consensus in favour of proposition to cryopreserve testicular tissue Exclusion Criteria: * Patients under the age of 3 months * Refusal of the patient and/or his parents * Treatments that are not highly gonadotoxic
References
Publications (0)
Data not yet available