Clinical trial · Observational
Possible Association of Intestinal Helminths and Protozoa With Colorectal Cancer Pathogenesis
Intestinal Helminths and Protozoan Infections in Patients With Colorectal Cancer: Prevalence and Possible Association With Cancer Pathogenesis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer (CRC) has the third highest cancer incidence in the world. There is mounting evidence that the intestinal microbiota plays an important role in colorectal carcinogenesis. but there is no information on protozoa of intestinal microbiota except Blastocystis hominis, although data on this issue is scarce. In this study we are going to evaluate the prevalence of intestinal helminthes and protozoa in CRC patients and control group that includes random residents. Patients will be examined before, after surgery and chemotherapy. Parasites and protozoan infection intensity will be estimated by triple coproscopy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Cancer Metastatic | — | UNRESOLVED | — |
| Intestinal Parasite | — | UNRESOLVED | — |
| Protozoan Infections | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Parasitological examination | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (8)
- label
- Patients with colorectal cancer
- description
- Patients hospitalized with colorectal cancer at the Department of Coloproctology of Republican Oncology Research Center.
- interventionNames
- Diagnostic Test: Parasitological examination
- label
- Population
- description
- The control group includes residents of Tashkent city without any complaints from gastrointestinal tract matched by gender and age to the patients with colorectal cancer.
- interventionNames
- Diagnostic Test: Parasitological examination
- label
- Patients with CRC without metastases
- description
- Patients hospitalized with colorectal cancer at the Department of Coloproctology of Republican Oncology Research Center.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * All patients with colorectal cancer before, after surgery and chemotherapy. For control group: * Includes all individuals that doesn't have any complaints from gastrointestinal tract Exclusion Criteria: * Age before 18. * Patients with other gastrointestinal disorders * Patients with any chronic concomitant diseases
References
Publications (1)
- RESULTToychiev A, Abdujapparov S, Imamov A, Navruzov B, Davis N, Badalova N, Osipova S. Intestinal helminths and protozoan infections in patients with colorectal cancer: prevalence and possible association with cancer pathogenesis. Parasitol Res. 2018 Dec;117(12):3715-3723. doi: 10.1007/s00436-018-6070-9. Epub 2018 Sep 15. PMID 30220046