Clinical trial · Interventional
Pilot Comparison of N-of-1 Trials of Light Therapy
Comparison of N-of-1 Trials of Light Therapy for Depressive Symptoms in Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study compares the effect of two N-of-1 trials on study compliance with an N-of-1 protocol and on satisfaction with participation in an N-of-1 trial. Using within-person analyses, the study also compares the effect of different types of light therapy on mood, fatigue, sleep, physical activity, and side effects within a mild to moderately depressed cancer survivor population. Ten participants will be randomized to the bright white versus dim red light therapy N-of-1 trial, while the remaining 5 participants will be randomized to a dim white versus dim red light comparator N-of-1 trial.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Depression | — | UNRESOLVED | — |
| Health Behavior | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fitbit Flex2 TM | Other | — | UNRESOLVED |
| Litebook® Advantage | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Bright white light vs dim red light
- description
- A balanced sequence (ABBA) over a 12 week period of bright white light and dim red light; alternating bright white and dim red light every 3 weeks. Subjects will receive 2 Litebook® Advantage lightboxes - 1 bright white and 1 dim red. Information such as mood, fatigue, sleep and light therapy side effects will be self-reported using a smartphone diary; physical activity and sleep will also be reported using a Fitbit Flex2 TM. Data visualization at 12 weeks.
- interventionNames
- Other: Litebook® Advantage
- Other: Fitbit Flex2 TM
- type
- ACTIVE_COMPARATOR
- label
- Dim white light vs dim red light
- description
- A balanced sequence (ABBA) over a 12 week period of dim white light and dim red light; alternating dim white and dim red light every 3 weeks. Subjects will receive 2 Litebook® Advantage lightboxes - 1 dim white and 1 dim red. Information such as mood, fatigue, sleep and light therapy side effects will be self-reported using a smartphone diary; physical activity and sleep will also be reported using a Fitbit Flex2 TM. Data visualization at 12 weeks.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: * History of cancer (not including basal cell or squamous cell carcinoma, or carcinoma in situ) * Current mild to moderate severity depressive symptoms (PHQ-8 score 5 to 19) * iPhone user Exclusion Criteria: * Has not completed primary cancer treatment including initial chemotherapy, surgical resection, or radiation therapy * Non-English speaking * Severe depression (PHQ-8 score \>=20) or active suicidal ideations * Other severe mental illness that would preclude participation in a study that requires extensive self-monitoring, including depression with psychotic features, other psychotic disorder, bipolar disorder, severe personality disorder * \<6 months life expectancy due to cancer or other severe medical illness * Other severe medical illness that would preclude ability to do daily self-tracking * Unavailable for follow-up over the course of the 3 month trial
References
Publications (0)
Data not yet available