Clinical trial · Interventional
Early Intrapleural TPA Instillation Versus Late
NCT03167281CI-TRIAL-00086289ELEVATEwithdrawnPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): lack of adequate recruitment
Summary
Brief summary (as posted)
Chest tubes are used for air or fluid removal from the pleural space. When a chest tube is placed, it can be hard for the fluid to drain.Tissue plasminogen activator (tPA) and DNase are given through the chest tube to help with draining the fluid. We are doing this research to see if early addition of tPA-DNase immediately after chest tube placement will help with better fluid draining.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Tissue Plasminogen Activator | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| early tPA and DNase | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- tPA and DNase
- description
- 10mg of t-PA and 5 mg of DNase in a 30 mL solution of water/saline administered via chest tube over three days twice daily 24-48 hours after chest tube placed.
- type
- EXPERIMENTAL
- label
- Early tPA and DNase
- description
- 10mg of t-PA and 5 mg of DNase in a 30 mL solution of water/saline administered via chest tube over three days twice daily with initial administration occurring at chest tube placement.
- interventionNames
- Combination Product: early tPA and DNase
Primary outcomes (1)
- measure
- Chest tube removal
- timeFrame
- 7 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients, age 18 years or older * Patients with an indication for a thoracostomy tube placement for a pleural effusion Exclusion Criteria: * Patients that require a thoracostomy tube for a pneumothorax * Pregnant women * Sensitivity to t-PA, or DNase * Patients taking carbamazepine or nitroglycerin * Lung volume reduction surgery on side of pleural effusion
References
Publications (0)
Data not yet available
No reference posted for this study.