Clinical trial · Interventional
Effect of a Topical Ketamine on Acute and Chronic Pain, Dose Finding
Effect of a Topical Ketamine on Acute and Chronic Post-mastectomy Pain, Dose Finding - Clinical Study
NCT03165149CI-TRIAL-00048054completedPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to investigate the effect of addition of different doses of Ketamine locally in acute and chronic post-mastectomy pain after breast cancer surgery and on the probability of developing chronic post-mastectomy pain.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| group (A) | Drug | — | UNRESOLVED |
| group (B) | Drug | — | UNRESOLVED |
| group (c) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Group (A)
- description
- patients will receive 1mg / kg of Ketamine diluted by 20 ml saline (0.9 % )
- interventionNames
- Drug: group (A)
- type
- ACTIVE_COMPARATOR
- label
- Group (B)
- description
- patients will receive 2 mg /kg of Ketamine diluted by 20 ml saline (0.9 %) a
- interventionNames
- Drug: group (B)
- type
- ACTIVE_COMPARATOR
- label
- Group (C)
- description
- patients will receive 3 mg / kg of Ketamine diluted by 20 ml saline (0.9 %)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: \- American society of heart association class I-II female patients * aged 18-60 years * scheduled for modified radical mastectomy with axillary dissection for breast carcinoma Exclusion Criteria: * known allergy to the study drugs * significant cardiac- * respiratory- * renal or hepatic disease
References
Publications (0)
Data not yet available
No reference posted for this study.