Clinical trial · Observational
Plasma ctDNA Detection in Diagnosis of Epithelial Ovarian Cancer.
NCT03155451CI-TRIAL-00029978ctDNA_EOCcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Epithelial ovarian cancer constitutes one of the most common gynecological malignancies.Because the ovaries lie in the deep pelvic cavity,most ovarian cancer patients are asymptomatic, rendering the majority often diagnosed at an advanced stage.ctDNA in cancer patients often bears similar genetic and epigenetic features to the related tumor DNA.This study aims to detect plasma ctDNA in Diagnosis of Epithelial Ovarian Cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Epithelial Ovarian Cancer | Ovarian Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| methylation markers screening | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Epithelial ovarian cancer
- description
- patients receive the ctDNA methylation markers screening
- interventionNames
- Diagnostic Test: methylation markers screening
Primary outcomes (1)
- measure
- Pathological diagnosis of ovarian lumps
- timeFrame
- One week after surgery
- description
- Pathological diagnosis of ovarian lumps，including immunohistochemical information and HE staining information.
Secondary outcomes (2)
- measure
- sensitivity (true positive rate)
- timeFrame
- 2 year
- description
- The proportion of persons with disease who have a positive test (positive test results among persons with disease)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * people aged 18years to 80years; * Diagnosis of ovarian cancer is confirmed by two Pathologists independently; * Pregnancy tests are negative. Exclusion Criteria: * With other type of malignancies; * someone who refuse to participate the study.
References
Publications (2)
- BACKGROUNDWen L, Li J, Guo H, Liu X, Zheng S, Zhang D, Zhu W, Qu J, Guo L, Du D, Jin X, Zhang Y, Gao Y, Shen J, Ge H, Tang F, Huang Y, Peng J. Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients. Cell Res. 2015 Nov;25(11):1250-64. doi: 10.1038/cr.2015.126. Epub 2015 Oct 30. PMID 26516143
- BACKGROUNDNick AM, Coleman RL, Ramirez PT, Sood AK. A framework for a personalized surgical approach to ovarian cancer. Nat Rev Clin Oncol. 2015 Apr;12(4):239-45. doi: 10.1038/nrclinonc.2015.26. Epub 2015 Feb 24. PMID 25707631