Clinical trial · Interventional
Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques
NCT03151564CI-TRIAL-00104682active not recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260915-000001
Summary
Brief summary (as posted)
To compare 2 different image creation/processing techniques during a standard CT scan in order to "see" problems in the liver and learn which method provides better image quality. The techniques use new artificial intelligence software to decrease image noise, which helps the radiologist to evaluate.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Carcinoma | Colon Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Colorectal Carcinoma | Colorectal Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Diseases of Liver | — | UNRESOLVED | — |
| Liver Metastases | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Computed Tomography Scan - 50% Dose Reduction | Diagnostic Test | — | UNRESOLVED |
| Computed Tomography Scan - 70% Dose Reduction | Diagnostic Test | — | UNRESOLVED |
| Deep Learning Image Reconstruction (DLIR) | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Computed Tomography Scan - 50% Dose Reduction
- description
- Participants undergo routine standard of care CT examination for colon carcinoma restaging, then have an additional scan of the liver at 50% dose reduction.
- interventionNames
- Diagnostic Test: Computed Tomography Scan - 50% Dose Reduction
- type
- EXPERIMENTAL
- label
- Computed tomography Scan - 70% Dose Reduction
- description
- Participants undergo routine standard of care CT examination for colon carcinoma restaging, then have an additional scan of the liver at 70% dose reduction.
- interventionNames
- Diagnostic Test: Computed Tomography Scan - 70% Dose Reduction
- type
- EXPERIMENTAL
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patient must be \>/= 18 years of age and \</=90 years of age 2. Men and non-pregnant women 3. Pathology proven diagnosis of colon or colorectal carcinoma 4. Liver metastases on most recent CT examination 5. Standard of care CT abdomen examination planned WITH IV contrast Exclusion Criteria: 1. Patients cannot give informed consent 2. Patients cannot undergo CT examination
References
Publications (2)
- DERIVEDJensen CT, Gupta S, Saleh MM, Liu X, Wong VK, Salem U, Qiao W, Samei E, Wagner-Bartak NA. Reduced-Dose Deep Learning Reconstruction for Abdominal CT of Liver Metastases. Radiology. 2022 Apr;303(1):90-98. doi: 10.1148/radiol.211838. Epub 2022 Jan 11. PMID 35014900
- DERIVEDJensen CT, Wagner-Bartak NA, Vu LN, Liu X, Raval B, Martinez D, Wei W, Cheng Y, Samei E, Gupta S. Detection of Colorectal Hepatic Metastases Is Superior at Standard Radiation Dose CT versus Reduced Dose CT. Radiology. 2019 Feb;290(2):400-409. doi: 10.1148/radiol.2018181657. Epub 2018 Nov 27. PMID 30480489