Clinical trial · Interventional
Diagnostic Imaging of Myeloma Bone Lesions
The Diagnostic Value of FDG-PET-CT, NaF-PET-CT and Whole-body MRI Compared to Whole-body Xray in the Detection of Bone Lesions in Multiple Myeloma Patients
NCT03147326CI-TRIAL-00027498RAMPcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare the current standard whole-body x-ray with the advanced imaging techniques FDG-PET-CT, NaF-PET-CT and whole-body MRI in the detection of myeloma bone lesions.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| FDG-PET-CT | Diagnostic Test | — | UNRESOLVED |
| NaF-PET-CT | Diagnostic Test | — | UNRESOLVED |
| Whole-body MRI | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- FDG-NaF-MRI
- description
- All participants will undergo three project scans/the following interventions: FDG-PET-CT NaF-PET-CT Whole-body MRI All participants will undergo a whole-body x-ray as part of clinical routine practice.
- interventionNames
- Diagnostic Test: FDG-PET-CT
- Diagnostic Test: NaF-PET-CT
- Diagnostic Test: Whole-body MRI
Primary outcomes (2)
- measure
- Bone metastases detection rate - a patient-based analysis
- timeFrame
- The three project scans will be performed once and as baseline scans within a maximum of 30 days from the performance of the whole-body x-ray. Image analyses and statistical tests will be done when all project scans have been performed
- description
- To compare the proportion of patients with bone disease detected by the four scanning techniques
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed multiple myeloma (biopsy proven) Exclusion Criteria: * Prior malignancy * Are not able to undergo a MRI scan due to MRI contraindications (e.g. pacemaker) * Has any condition that places the subject at an unacceptable risk if he/she undergoes a diagnostic CT scan with iv. contrast (e.g. history of severe allergic reaction to the contrast agent) * Severe claustrophobia
References
Publications (0)
Data not yet available
No reference posted for this study.