Clinical trial · Interventional
Study of Xeloxiri Regimen for Patients With Refractory Metastatic Colorectal Cancer
An Open-label, Single-centre, Single-arm Phase II Study of Triplet Combination of Capecitabine, Oxaliplatin and Irinotecan (Xeloxiri) as Salvage Therapy in Patients With Refractory Metastatic Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is an open-label, single centre, single-arm phase II study which aims to assess the efficacy and tolerability of triplet combination of capecitabine, oxaliplatin and irinotecan (Xeloxiri regimen) in treating patients with refractory metastatic colorectal cancer. Clinical data from patients diagnosed with colorectal cancer will be collected and analyzed in this study. The patients' data will be collected and maintained in the Division of medical oncology of the Department of Medicine, Queen Mary Hospital.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Capecitabine | Drug | Capecitabine | ALIAS |
| Irinotecan | Drug | Irinotecan | ALIAS |
| Oxaliplatin | Drug | Oxaliplatin | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Xeloxiri
- interventionNames
- Drug: Capecitabine
- Drug: Oxaliplatin
- Drug: Irinotecan
Primary outcomes (1)
- measure
- Objective response rate
- timeFrame
- Change from baseline in size approximately every 8 weeks (4 cycles), up to approximately 12 months
Secondary outcomes (2)
- measure
- Progression-free survival
- timeFrame
- From date of start until the date of first documented progression or death from disease-related causes or last follow-up, whichever came first, assessed up to 18 months
- measure
- Overall survival
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults ≥ 18 years of age, male or female. * Histopathologically or cytologically confirmed adenocarcinoma. * Failed ≥ 2 lines of standard therapy which must include a fluoropyrimidine, oxaliplatin and/or irinotecan, administered either as monotherapy or doublets. * ECOG performance status 0 to 2. * Adequate bone marrow reserve. * Absolute neutrophil count \> 1 × 109/L. * Total bilirubin \< 3 × the upper limit of the normal range. * Life expectancy ≥ 12 weeks. * Signed written informed consent form. Exclusion Criteria: * Prior malignant disease other than colorectal cancer within 5 years of study entry. * Patients suitable for surgical or locoregional therapies. * Patients unable to swallow oral medications. * Any evidence of brain metastasis (unless the patient is \>6 months from definitive therapy, has a negative imaging study within 4 weeks of study entry and is clinically stable with respect to the tumor at the time of study entry). * Active clinically serious infections (\> grade 2 NCI / CTC Adverse Event version 3.0). * History of allergy to platinum compounds. * Patients who have chronic inflammatory bowel disease and/or bowel obstruction. * Patients who have severe bone marrow failure. * Patients undergoing renal dialysis. * History of HIV infection. * Seizure disorder requiring medication (such as steroids or anti-epileptics). * Women who are pregnant or breast-feeding, or women of child-bearing potential who are unable or unwilling to practice a highly effective means of contraception. * Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of study results.
References
Publications (0)
Data not yet available