Clinical trial · Interventional
Electric Stimulation on Nausea and Vomit Chemotherapy Induced
Transcutaneous Electric Nerve Stimulation Effects on Nausea and Vomit Chemotherapy-induced
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chemotherapy induces nausea and vomit for some large patients. But, some chemotherapy protocol has a high indices of the incidence as observed in a combination of Anthracycline and Cyclophosphamide (AC). To prevent this symptoms, some medication can be used as Ondansetron. By other hands, the traditional acupuncture on Chinese Medicine have been used a PC6 point to avoid nausea and vomit. More recently, a transcutaneous electric nerve stimulation (TENS) also has been used for this application. Our study will test the TENS applied on PC6 point with two different frequencies (high and low) to evaluated the nausea and vomit inhibition effects.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acupuncture | — | UNRESOLVED | — |
| Breast Cancer Female | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High Frequency Group | Device | — | UNRESOLVED |
| Low Frequency Group | Device | — | UNRESOLVED |
| Placebo Group | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- PLACEBO_COMPARATOR
- label
- Placebo Group
- description
- Placebo Group: In this group the participants received TENS with frequency of 75Hz, pulse duration of 200 microseconds. The stimulation time will be for only 10s.
- interventionNames
- Device: Placebo Group
- type
- EXPERIMENTAL
- label
- Low Frequency Group
- description
- Low Frequency Group: In this group the TENS will be adjusted with frequency of 10Hz, pulse duration of 200 microseconds. The stimulation time will be 30 minutes and the intensity will be constantly adjusted in order to keep as high as possible within the tolerance threshold of the patient.
- interventionNames
- Device: Low Frequency Group
- type
- EXPERIMENTAL
- label
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Having breast cancer diagnosed through anatomopathological investigation; * Indication of neoadjuvant or adjuvant chemotherapy treatment with the combination of anthracycline and cyclophosphamide associated with Ondasetron used as a routine of the Santa Rita Hospital chemotherapy service; * Present Karnofsky score (KPS) higher than 70 points; * Being female; * Be between 18 and 65 years of age and be able to participate in outpatient chemotherapy. Exclusion Criteria: * Patients with breast cancer treated with chemotherapeutic regimens other than anthracycline and cyclophosphamide; * Inability to report nausea and vomiting due to neurological changes, difficulty understanding and / or lack of caregivers that may contribute to the completion of the report; * Be submitted to radiation therapy concomitant with chemotherapy; * Presence of gastrointestinal and cerebral metastases; * Presence of cardiac pacemaker; * Presence of active skin infection in PC6; * Nausea and vomiting caused by electrolyte disturbances or intestinal; * Presence of intra-cranial hypertension.
References
Publications (0)
Data not yet available