Clinical trial · Observational
Surgical Anatomy and 'Waisting' of the sIgmoid SpEcimen
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Treatment of rectal cancer has improved to the extent that its local recurrence rates are now much lower than other sites in the large bowel. It has been found that higher rates of recurrence in the sigmoid section of the colon, just before the rectum. This might be due to a narrowing in the bowel, and difficulties identifying whether cancers are in the sigmoid or rectum. The aim is to investigate the bowel from 20 patients undergoing surgery for left sided colorectal cancer at the Royal Marsden. These patients would have routine investigations and treatments, but once the bowel has been removed, it would undergo a MRI scan and additional slices and photography during pathological analysis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sigmoid, Sigmoid Colon, Neoplasm, Cancer | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Height from peritoneal reflection to the mesorectal apex in mm, from the pathology specimen.
- timeFrame
- 48 hours post-surgery
- description
- Photographs will be captured of the macroscopic whole specimen and serial cross sectional slices using a high definition camera and will be used to perform the necessary measurements for the study.
- measure
- The area of tissue in mm2 within the mesentery, from the pathology specimen.
- timeFrame
- 48 hours post-surgery
- description
- Photographs will be captured of the macroscopic whole specimen and serial cross
Secondary outcomes (7)
- measure
- Distance in mm from the anterior peritoneal reflection to the rectosigmoid junction on MRI (mesorectal apex, insertion of the superior rectal artery, sacral promontory, inferior border of S2) vs pathology specimen (coalescence of taenia coli).
- timeFrame
- 48 hours post-surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients over the age of 18 years with rectal or sigmoid cancer who will be undergoing left sided colorectal resection including the anterior peritoneal reflection. * Patients must be able to undergo colonoscopy, adequate bowel preparation, MRI and surgery. Exclusion Criteria: * Patients who are unable to consent, withhold consent or withdraw consent, including patients who require an emergency operation and will be unable to give informed consent * Contraindication to MRI as per MHRA recommendations \[36\] eg implanted medical devices, severe claustrophobia * Distortion of the sigmoid mesentery due to tumour perforation, invasion (stage T4), or extreme bulk
References
Publications (0)
Data not yet available