Evaluate the Hematological Remission Rates and Survival Among Chinese Adult Patients With B-precursor ALL

Although the response rate by first-line treatment has been improved, most adult patients with relapsed or refractory ALL will eventually relapse with poor outcomes regardless of treatments. To further understand current status of the treatment of adult patients with relapsed or refractory ALL in China, the study retrospectively collected diagnosis and treatment data from ALL patients in 14 centers in China. Primary objective: to estimate the proportion of patients in overall response rate (ORR) for early relapsed or primary refractory Philadelphia chromosome negative (Ph-) B-precursor ALL patients following salvage treatment (i.e., proportion of patients in hematological complete remission \[CR\] and CR with partial recovery of blood cells \[CRh\*\]); Secondary objectives included: to estimate the proportion of patients in CR, CRh\* and CRi(CR/CRh\*/CRi) and the duration of CR/CRh\*/CRi, overall survival, duration of CR/CRh\*and the proportion of patients receiving allogeneic hematopoietic stem cell transplantation (AlloHSCT) for early relapsed/primary refractory Ph-B-precursor ALL patients following salvage treatment; Exploratory objectives included: to estimate the efficacy in late relapsed Ph- B-precursor ALL (first remission duration \> 12 months) patients and in Ph+ B-precursor ALL patients and specific subgroup patients following salvage treatment.

Sex

All

Minimum age

15 Years

Inclusion Criteria:

* Chinese adult patients with R/r B-precursor ALL who had received salvage treatment
* At least one complete response evaluation results available for salvage treatment
* With definite Ph chromosome status
* Age ≥15 years at time of de novo (initial) diagnosis of ALL.
* For relapsed patients who met the above conditions must also have
* Evaluable duration of CR by initial therapy
* No central nervous system involved at relapsed
* No isolated extramedullary relapse Patients were divided into 3 analysis sets based on molecular genetic factor and type, and time from initial response to relapse.
* Ph- Primary Analysis Set included patients who are diagnosed with Ph- disease and meet one of the following criteria:
* in first relapse or salvage treatment after a first complete remission duration of ≤12 months, or refractory to initial treatment, or relapsed/refractory after first or subsequent salvage treatment, or Relapsed/refractory within 12 months after alloHSCT.
* The Ph- Late Relapse Analysis Set included patients who had a first remission duration of \>12 months and were in first relapse or salvage treatment.
* The Ph+ Analysis Set included patients who were diagnosed with Ph+ disease.

Exclusion Criteria:

\-

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