Mesylate Apatinib for Stage Ⅳ STS After Failure of Chemotherapy

Inclusion Criteria:

* Patients voluntarily join the study, signed informed consent, good compliance;
* The pathology was diagnosed as stage Ⅳ soft tissue sarcoma patients, clinical staging using the American Cancer Research Joint Committee (AJCC) TNM staging criteria. According to CT or MRI at least one measurable lesion;
* At least one chemotherapy regimen (containing anthracycline) was treated and evaluated as "disease progression" in terms of the efficacy evaluation criteria of solid tumors (RECIST 1.1).
* 18 to 70 years old, PS score: 0 \~ 2; expected survival period of more than 3 months;
* The laboratory check meets the following criteria:
* Blood routine examination: HB ≥ 100g / L (14 days without blood transfusion); ANC ≥ 1.5 × 109 / L; PLT ≥ 80 × 109 / L
* Biochemical tests: serum creatinine Cr ≤ normal upper limit (ULN), bilirubin BIL ≤ normal upper limit (ULN), ALT, AST ≤ 1.5 × normal upper limit (ULN), for liver metastases ≤ 5 × normal upper limit (ULN); fasting triglyceride ≤ 3.0mmol / L, fasting cholesterol ≤ 7.75mmol / L;
* Doppler ultrasonography: left ventricular ejection fraction (LVEF) ≥ normal low (50%).
* Women should agree that contraceptive measures (such as IUDs, contraceptives or condoms) must be used within six months of the study period and after the end of the study; serum or urine pregnancy studies were negative for 7 days prior to study , and must be non-lactating patients; men should agree that contraceptive measures must be used within six months of the study period and after the end of the study period.

Exclusion Criteria:

* Patients who have received antiangiogenic therapy or other targeted treatment for no more than 3 months, such as Endostar, Erlotinib, Sunitinib, Sorafenib, Avastin, Imatinib, Famitinib, Pazopanib and other drugs.
* Past or concurrent with other malignancies, except for cured skin basal cell carcinoma and cervical in situ cancer;
* Participated in other drug clinical researchers within four weeks;
* Previously received anticancer treatment patients with NCI CTC AE grade\> 1 grade toxicity;
* Have a variety of factors that affect oral medication (such as can not swallow, gastrointestinal resection, chronic diarrhea and intestinal obstruction, etc.)
* Known brain metastases, spinal cord compression, cancerous meningitis, or screening when the CT or MRI examination found that the brain or pia mater disease;
* Patients with any severe and / or uncontrolled disease, for example:
* Unstable angina, symptomatic congestive heart failure, myocardial infarction within 6 months prior to randomization, severe uncontrollable arrhythmia; poor blood pressure control (systolic blood pressure\> 140 mmHg, diastolic blood pressure\> 90 mmHg )patient;
* Active or uncontrollable serious infection;
* Liver diseases such as cirrhosis, decompensated liver disease, chronic active hepatitis;
* Poor control of diabetes (fasting blood glucose (FBG)\> 10mmol / L);
* Urinary routine urinary protein ≥ ++, and confirmed 24 hours urine protein\> 1.0 g;
* Long untreated wound or fracture;
* Patients with bleeding tendency (such as active gastrointestinal ulcers) or treated with anticoagulants or vitamin K antagonists such as warfarin, heparin or analogues;
* Interventional venous thrombosis events such as cerebrovascular accident (including transient ischemic attack), deep vein thrombosis, and pulmonary embolism before the first medication.
* Have a history of psychiatric abuse and can not quit or have mental disorders;
* Have a history of immunodeficiency, including HIV testing positive or other acquired, congenital immune deficiency disease, or a history of organ transplantation;
* According to the researcher's judgment, there are serious illnesses that compromise the patient's safety or affect the patient's completion of the study.