Clinical trial · Observational
Functional Imaging in Lung SBRT
Functional Outcomes for Stereotactic Body Radiotherapy of Lung Lesions in High Risk Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Little is known about the safety of body radiation therapy (SBRT), especially the impact on pulmonary function, quality of life, and on functional changes within the lung itself. Radiation dose constraints and capturing functional changes on imaging are not well studied in this setting. The current study aims to evaluate the utility of advanced imaging to measure lung function prior to and after treatment and to assess the feasibility of using this data to adapt SBRT planning.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (8)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Biological Sample Collection | Other | — | UNRESOLVED |
| Cardiac Assessment | Other | — | UNRESOLVED |
| CT Scan | Other | — | UNRESOLVED |
| Lung CT | Other | — | UNRESOLVED |
| MRI | Other | — | UNRESOLVED |
| SGRQ | Other | — | UNRESOLVED |
| Toxicity | Other | — | UNRESOLVED |
| Walk Test | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- High Risk Lung Cancer Patients
- interventionNames
- Other: CT Scan
- Other: Lung CT
- Other: MRI
- Other: Walk Test
- Other: SGRQ
- Other: Biological Sample Collection
- Other: Toxicity
- Other: Cardiac Assessment
Primary outcomes (1)
- measure
- Longitudinal Changes in Lung Function
- timeFrame
- From baseline to 6 months post Radiation Treatment
- description
- To characterize longitudinal changes in lung function using SPECT/CT and CT ventilation scans in "high risk" patients undergoing standard SBRT treatments.
Secondary outcomes (3)
- measure
- Dosimetric Predictors to Assess Changes in Toxicity
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients receiving SBRT lung treatment and who have any one of the following high risk features: * Lung lesion \> 5 cm * DLCO \< 35% * FEV1 \< 0.5 L * Central lung tumors (defined as within 2 cm from the proximal bronchial tree) * Tumors that abut the great vessels, trachea, spinal cord, or esophagus * Prior lobectomy or pneumonectomy * Prior lung radiation (SBRT or conventional definitive lung radiation) * Patients must be 18 years of age or older Exclusion Criteria: * Patients who have received targeted agents or systemic potentially radiosensitizing chemotherapy within 2 weeks of lung SBRT start * Pregnancy or lactation * Unable to tolerate MRI without anesthesia * Inability cooperate with the scans
References
Publications (0)
Data not yet available