Clinical trial · Observational
Preoperative Estimation of Microvascular Invasion in Hepatocellular Carcinoma
Nomogram for Preoperative Estimation of Microvascular Invasion Risk in Hepatocellular Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Presence of microvascular invasion can be estimated preoperatively, by some clinical imaging features such as patient characteristics, serum biomarkers and radiological features. Contrast-enhanced ultrasonography (CEUS) and contrast-enhanced computed tomography (CECT) are routine preoperative conventional examinations for hepatocellular carcinoma (HCC) patients in China. Combining features of CEUS, CECT and clinical factors may improve preoperative MVI assessment. The purpose of this study is to construct a nomogram for preoperative MVI risk estimation with these possible factors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| contrast-enhanced computed tomography | Diagnostic Test | — | UNRESOLVED |
| contrast-enhanced ultrasound | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Preoperative clinical/imaging features
- description
- In this project, there is only one study group which comprises of patients with Hepatocellular Carcinoma (HCC) who will undergo contrast-enhanced computed tomography (CECT) and contrast-enhanced ultrasound (CEUS).
- interventionNames
- Diagnostic Test: contrast-enhanced ultrasound
- Diagnostic Test: contrast-enhanced computed tomography
Primary outcomes (1)
- measure
- Presence of microvascular invasion
- timeFrame
- Through patient enrollment completion, an average of 2 years
- description
- Postoperative histologically confirmed microvascular invasion
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Asian patients aged 18～80 years old; * With no preoperative anti-cancer treatment; * Scheduled for radical liver resection; * With both CEUS and CECT performed in 4 weeks before surgery; * Postoperative histologically confirmed HCC; * With sufficient surgical specimen for MVI detection (surgical margin ≥1cm); Exclusion Criteria: * Recurrent HCC or combined hepatocellular-cholangiocarcinoma; * With extra-hepatic metastasis or macrovascular invasion; * With incomplete clinical and imaging data; * Non-radical resection;
References
Publications (3)
- BACKGROUNDLei Z, Li J, Wu D, Xia Y, Wang Q, Si A, Wang K, Wan X, Lau WY, Wu M, Shen F. Nomogram for Preoperative Estimation of Microvascular Invasion Risk in Hepatitis B Virus-Related Hepatocellular Carcinoma Within the Milan Criteria. JAMA Surg. 2016 Apr;151(4):356-63. doi: 10.1001/jamasurg.2015.4257. PMID 26579636
- BACKGROUNDZhao H, Hua Y, Dai T, He J, Tang M, Fu X, Mao L, Jin H, Qiu Y. Development and validation of a novel predictive scoring model for microvascular invasion in patients with hepatocellular carcinoma. Eur J Radiol. 2017 Mar;88:32-40. doi: 10.1016/j.ejrad.2016.12.030. Epub 2016 Dec 27. PMID 28189206
- BACKGROUNDFeng LH, Dong H, Lau WY, Yu H, Zhu YY, Zhao Y, Lin YX, Chen J, Wu MC, Cong WM. Novel microvascular invasion-based prognostic nomograms to predict survival outcomes in patients after R0 resection for hepatocellular carcinoma. J Cancer Res Clin Oncol. 2017 Feb;143(2):293-303. doi: 10.1007/s00432-016-2286-1. Epub 2016 Oct 14. PMID 27743138