Clinical trial · Interventional
Yttrium-90 (Y90) Glass Microspheres PET/CT in Imaging Patients With Liver Tumors
High Quality Imaging and Dosimetry of Yttrium-90 (90Y) SIRT Using a Digital PET/CT
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial studies how well yttrium-90 (Y90) glass microspheres positron emission tomography (PET)/computed tomography (CT) works in imaging patients with liver tumors . Images produced by PET/CT may provide better information about the distribution of particles, such as Y90 glass microspheres, delivered for selective internal radiation therapy (SIRT) as compared to regular medical care images useing technetium Tc-99m albumin-aggregated single photon emission computed tomography (SPECT)/CT images.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Primary Malignant Liver Neoplasm | Primary Malignant Liver Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 90-Yttrium (Y-90) Glass Microspheres | Device | — | UNRESOLVED |
| Computed Tomography (CT) | Procedure | — | UNRESOLVED |
| Positron Emission Tomography (PET) | Procedure | — | UNRESOLVED |
| Single-photon emission computerized tomography (SPECT) scan | Procedure | — | UNRESOLVED |
| Technetium 99mTc albumin aggregated (99mTc-MAA) | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Yttrium Y-90 PET/CT vs 99mTc-MAA SPECT/CT Scans
- description
- All participants receive both Y-90 PET/CT vs 99mTc-MAA SPECT/CT Scans
- interventionNames
- Procedure: Computed Tomography (CT)
- Procedure: Positron Emission Tomography (PET)
- Device: 90-Yttrium (Y-90) Glass Microspheres
- Diagnostic Test: Technetium 99mTc albumin aggregated (99mTc-MAA)
- Procedure: Single-photon emission computerized tomography (SPECT) scan
Primary outcomes (1)
- measure
- Image Quality for 90-Y PET/CT Scans
- timeFrame
- 1 day
- description
- Image quality for 90Y PET/CT scan images was assessed relative to the expected image quality of Standard of Care (SoC) 99mTc-MAA SPECT/CT scans obtained from the same participant. Assessments were conducted at 5, 10, 15 and 20 minutes after infusion. Scans were assessed on a 1 to 5 Likert scale by 2 Nuclear Medicine physicians who were blinded to patient information. The Likert scale for image quality was established as follows: 1. = Non-diagnostic 2. = Suboptimal 3. = Acceptable 4. = Good 5. = Excellent, equivalent to a SoC 99mTc-MAA SPECT/CT scan The scans for each individual participant at each timepoint was scored on the Likert scale, as determined by the 2 Nuclear Medicine physicians. The outcome is reported as the overall mean of the physician determinations for each time point, with standard deviation.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient provides written informed consent * Patient is referred for 90Y SIRT radioembolization of liver tumor(s) * Patient is capable of complying with study procedures * Patient is able to remain still for duration of imaging procedure (approximately 30 minutes total for digital PET/CT) Exclusion Criteria: * Patient is pregnant or nursing
References
Publications (1)
- RESULTDuan H, Khalaf MH, Ferri V, Baratto L, Srinivas SM, Sze DY, Iagaru A. High quality imaging and dosimetry for yttrium-90 (90Y) liver radioembolization using a SiPM-based PET/CT scanner. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2426-2436. doi: 10.1007/s00259-021-05188-4. Epub 2021 Jan 14. PMID 33443618