Clinical trial · Interventional
Sublobar Resection Versus Lobectomy for cT1N0M0 Non-small-cell Lung Cancer
A Multi-center, Randomized-controlled, Open-label Clinical Trial: Sublobar Resection Versus Lobectomy for cT1N0M0 Non-small-cell Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The incidence rate of ground-glass opacity (GGO) has been increasing these years. A great number of retrospective studies suggested that sublobar resection was better for some GGO patients. However, no prospective clinical study supports the perspective. This study is prospective, multi-center, randomized-controlled. The aim of this study is to investigate whether sublobar resection is inferior to lobectomy for cT1N0M0 non-small-cell lung cancer or not.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Non-Small-Cell Lung | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| lobectomy | Procedure | — | UNRESOLVED |
| sublobar resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Sublobar group
- description
- Patients receive sublobar resection, including wedge resection and segmentectomy.
- interventionNames
- Procedure: sublobar resection
- type
- ACTIVE_COMPARATOR
- label
- Lobectomy group
- description
- Patients receive lobectomy.
- interventionNames
- Procedure: lobectomy
Primary outcomes (1)
- measure
- Overall Survival
- timeFrame
- five years after surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * cT1N0M0 non-small-cell lung cancer * ground-glass opacity, ≤2cm, GGO≥25% * eligible for both lobectomy and sublobar resection * intraoperative pathology is minimally-invasive adenocarcinoma or invasive adenocarcinoma * intraoperative pathology of biopsied station 10 lymph node is negative Exclusion Criteria: * intraoperative pathology is benign nodule, atypical adenomatous hyperplasia, or adenocarcinoma in-situ * intraoperative pathology of biopsied station 10 lymph node is positive * multiple GGOs, lesions other than dominant lesion are malignant or \>5mm * history of thoracic surgery * history of malignancy in recent 5 years * unstable systemic disease * patients with psychiatric disorders
References
Publications (0)
Data not yet available