Clinical trial · Interventional
Impact of Cognitive Rehab and Physical Activity on Cognition in Patients With Metastatic Brain Tumors Undergoing RT
Does Cognitive Rehabilitation and Physical Activity Impact Executive Functioning Following Radiation Therapy for Cerebral Metastases? A Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): PI leaving institution: Will not continue study.
Summary
Brief summary (as posted)
To determine the feasibility of processes and instruments with an overarching purpose to guide the design of a larger study. To determine the feasibility of individuals with metastatic brain tumor(s) to engage in physical activity(PA) and cognitive rehabilitation (CR) as in an outpatient therapy setting.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cerebral Metastases | — | UNRESOLVED | — |
| Metastatic Brain Tumor | Brain Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cognitive rehabilitation | Behavioral | — | UNRESOLVED |
| Physical Activity | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Arm 1: Physical activity intervention
- description
- Undergo baseline testing of physical (lower body strength, endurance) and cognitive (executive functioning) abilities. 14 days (± 2 days) following WBRT/SRS: all arms undergo testing of physical (lower body strength, endurance) and cognitive (executive functioning) abilities. Arm 1: intervention of physical activity begins. 60 days (± 5 days) post testing after WBRT/SRS: all arms undergo final testing of physical (lower body strength, endurance) and cognitive (executive functioning) abilities.
- interventionNames
- Behavioral: Physical Activity
- type
- ACTIVE_COMPARATOR
- label
- Arm 2:Physical activity and cognitive intervention
- description
- Undergo baseline testing of physical (lower body strength, endurance) and cognitive (executive functioning) abilities. 14 days (± 2 days) following WBRT/SRS: all arms undergo testing of physical (lower body strength, endurance) and cognitive (executive functioning) abilities. Arm 2: intervention of both cognitive rehabilitation and physical activity begins. 60 days (± 5 days) post testing after WBRT/SRS: all arms undergo final testing of physical (lower body strength, endurance) and cognitive (executive functioning) abilities.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * A potential subject must meet all of the following inclusion criteria to be eligible to participate in the study: * Ability to understand and the willingness to provide written informed consent * 18 years of age and older * Diagnosed with one or more metastatic brain tumor(s) * Medical treatment plan includes whole-brain radiation therapy and / or sterotactic radiosurgery Exclusion Criteria: * A potential subject who meets any of the following exclusion criteria is ineligible to participate in the study. * Diagnosis of dementia or unable to grant their own informed consent * Prisoner or patient in custody * Patient on psychiatric hold * Physically unable to participate in the study * The opinion of the treating physician determines it is not medically safe to participate in the study * Pre-registration screen of cognition is "severe" or lower.
References
Publications (0)
Data not yet available