Clinical trial · Interventional
Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer
NCT03089125CI-TRIAL-00086516completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research study is evaluating a behavioral intervention designed to help people with advanced lung cancer manage dyspnea (i.e., breathlessness or shortness-of-breath).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dyspnea Intervention | Behavioral | — | UNRESOLVED |
| Usual Care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Usual Care
- description
- Patients will receive any usual care for their dyspnea as deemed appropriate by their clinicians.
- interventionNames
- Other: Usual Care
- type
- EXPERIMENTAL
- label
- Dyspnea Intervention
- description
- Dyspnea intervention will be administered over two sessions Patients will receive: * Psychoeducation * Relaxation training for reducing physiological stress * Behavioral techniques for managing acute breathlessness
- interventionNames
- Behavioral: Dyspnea Intervention
- Other: Usual Care
Primary outcomes (2)
- measure
- Modified Medical Research Council Dyspnea Scale (mMRCDS)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * A diagnosis of either NSCLC, SCLC, or mesothelioma, not being treated with curative intent * Self-reported shortness of breath (a score of 2 or greater on the Modified Medical Research Council Dyspnea Scale) * Eastern Cooperative Oncology Group (ECOG) Performance Status from 0 (asymptomatic) to 2 (symptomatic and in bed \<50% of day) * The ability to read and respond to questions English * Primary cancer care at the Massachusetts General Hospital (MGH) Cancer Center or Dana-Farber Cancer Institute (DFCI) * Age \>18 years Exclusion Criteria: * Cognitive or psychiatric conditions prohibiting study consent or participation. * A treating clinician who reports that the patient is inappropriate for the study
References
Publications (1)
- DERIVEDGreer JA, Post KE, Chabria R, Aribindi S, Brennan N, Eche-Ugwu IJ, Halpenny B, Fox E, Lo S, Waldman LP, Pintro K, Rabideau DJ, Pirl WF, Cooley ME, Temel JS. Randomized Controlled Trial of a Nurse-Led Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer. J Clin Oncol. 2024 Oct 20;42(30):3570-3580. doi: 10.1200/JCO.24.00048. Epub 2024 Aug 1. PMID 39088766