Study Evaluating the Efficacy and Safety With CAR-T Immunotherapy for CD19 Positive Lymphoma

Inclusion Criteria:

* 1.Age older than 16 years old,gender and race no limited.
* 2.Pathological diagnosis of CD19 express positive recurrent or refractory B lymphoma, satisfy any of the following a diagnosis of recurrent or refractory lymphoma: (1) According to the standard solution standardization more than four courses of treatment, tumor size \< 50% or progression;(2) According to the standard solution treatment of complete remission, after recurrence again with the original plan or the national expert consensus recommended second-line cannot again get to complete remission (3) Relapse after hematopoietic stem cell transplantation.
* 3.Patients into the group needs lesions to be available for testing or evaluating disease.
* 4.ECOG score reaches 0 to 1 points.
* 5.Patients into the group of White Blood Cell counts in peripheral blood acuity≥ 1.0 x10\^9 / L.
* 6.Estimated survival times \> 90 days.
* 7.Patients have self-knowledge ability, can sign the informed consent form.

Exclusion Criteria:

* 1.Pregnant or lactating women.
* 2.Uncontrolled infection.
* 3.HIV infection, hepatitis B or C activity period.
* 4.Patients who need long-term immunosuppressive therapy (Such as allergies, autoimmune diseases, GVHD, etc.)
* 5.Combined activity of the central nervous system malignant tumor invasion.
* 6.Abnormal coagulation function, patients with severe thrombosis.
* 7\. Organ failure Heart：class Ⅱ or above. Liver：class Ⅱ or above( Refer to Classification of Wuhan Conference (1983)). Kidney: The second stage of renal insufficiency or above. Lung: class Ⅱdecreased slightly or above. Brain: The central nervous system transfer or have active lesions.
* 8.Patients who have participated in other clinical trials in the past 30 days or or participate in other clinical trials at the same time.
* 9.Investigator believe that the patient is not suitable to participate in the study.